从恶性副蛋白血症患者体内快速清除异常蛋白的方法。
Method of removing abnormal protein rapidly from patients with malignant paraproteinaemias.
作者信息
Powles R, Smith C, Kohn J, Hamilton Fairley G
出版信息
Br Med J. 1971 Sep 18;3(5776):664-7. doi: 10.1136/bmj.3.5776.664.
On 48 occasions large quantities of abnormal protein were removed from the blood of 11 patients with malignant paraproteinaemias (plasmacytomas) by exchanging their plasma with reconstituted blood bank plasma. The IBM continuous flow blood cell separator was used to exchange the plasma, a procedure that is safe, very rapid, and with clinical benefits which are much better than can be obtained by conventional plasmapheresis. In addition, the constituents of reconstituted plasma correct deficiencies in normal immunoglobulins found in these patients. Clearly for the management of some patients with paraproteinaemia a cell separator is essential.
在48次治疗中，通过用重组血库血浆置换11例恶性副蛋白血症（浆细胞瘤）患者的血浆，从他们的血液中清除了大量异常蛋白质。使用IBM连续流动血细胞分离器进行血浆置换，该方法安全、快速，临床效果比传统血浆置换要好得多。此外，重组血浆的成分可纠正这些患者体内正常免疫球蛋白的缺乏。显然，对于一些副蛋白血症患者的治疗，血细胞分离器是必不可少的。
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