Chang An-Yi, Lin Muyang, Yin Lu, Reynoso Maria, Ding Shichao, Liu Ruixiao, Dugas Yuma, Casanova Ana, Park Geonho, Li Zhengxing, Luan Hao, Askarinam Nelly, Zhang Fangyu, Xu Sheng, Wang Joseph
Aiiso Yufeng Li Family Department of Chemical and Nano Engineering, University of California San Diego, La Jolla, CA, USA.
Nat Biomed Eng. 2025 Jul 2. doi: 10.1038/s41551-025-01439-z.
The development of closed-loop systems towards effective management of diabetes requires the inclusion of additional chemical and physical inputs that affect disease pathophysiology and reflect cardiovascular risks in patients. Comprehensive glycaemic control information should account for more than a single glucose signal. Here, we describe a hybrid flexible wristband sensing platform that integrates a microneedle array for multiplexed biomarker sensing and an ultrasonic array for blood pressure, arterial stiffness and heart-rate monitoring. The integrated system provides a continuous evaluation of the metabolic and cardiovascular status towards improving glycaemic control and alerting patients to cardiovascular risks. The multimodal platform offers continuous glucose, lactate and alcohol monitoring, along with simultaneous ultrasonic measurements of blood pressure, arterial stiffness and heart rate, to support understanding of the interplay between interstitial fluid biomarkers and physiological parameters during common activities. By expanding the continuous monitoring of patients with diabetes to additional biomarkers and key cardiac signals, our integrated multiplexed chemical-physical health-monitoring platform holds promise for addressing the limitations of existing single-modality glucose-monitoring systems towards enhanced management of diabetes and related cardiovascular risks.
闭环系统向有效管理糖尿病发展需要纳入额外的化学和物理输入，这些输入会影响疾病病理生理学并反映患者的心血管风险。全面的血糖控制信息应不止包含单一的葡萄糖信号。在此，我们描述了一种混合柔性腕带传感平台，该平台集成了用于多重生物标志物传感的微针阵列和用于血压、动脉僵硬度及心率监测的超声阵列。该集成系统对代谢和心血管状态进行持续评估，以改善血糖控制并提醒患者注意心血管风险。这个多模态平台可进行连续的葡萄糖、乳酸和酒精监测，同时对血压、动脉僵硬度和心率进行超声测量，以支持理解日常活动期间组织间液生物标志物与生理参数之间的相互作用。通过将糖尿病患者的连续监测扩展到额外的生物标志物和关键心脏信号，我们的集成多重化学 - 物理健康监测平台有望解决现有单模态血糖监测系统在加强糖尿病及相关心血管风险管理方面的局限性。
