Wang Xin, Liu Wanqiu, Hu Mingda, Ma Hui, He Yaqing, Wang Boqian, Li Kexin, Zhang Rui, Fu JingJing, Zhang Hailong, Chen Long, Zhao Xinru, Aimaiti Buaijier, Song Hongbin, Ren Hongguang, Hu Xiaofeng
Laboratory of Advanced Biotechnology, Beijing Institute of Biotechnology, Beijing, China.
School of Public Health, University of South China, Hengyang, China.
Front Cell Infect Microbiol. 2025 Jun 18;15:1593610. doi: 10.3389/fcimb.2025.1593610. eCollection 2025.
Norovirus is a key pathogen of acute gastroenteritis and poses a significant burden on both the economy and public health. This study focuses on continuous monitoring of norovirus in Shenzhen, China, from 2016 to 2022, aiming to analyze the epidemic characteristics and genetic diversity of norovirus in the context of global sequence data.
The study was based on data collected from local sentinel hospitals. It involved analyzing the demographic, spatial, and temporal distribution of norovirus infections. Phylogenetic analysis was conducted, and genotype dynamics were compared across geographic levels. Mutations affecting protein stability were evaluated, and recombination analysis was performed to identify critical breakpoints and fragments for norovirus.
The study found that norovirus primarily infected infants under 3 years old, with epidemics occurring in winter and concentrated in developed districts. Phylogenetic analysis revealed both similarities and differences in the evolutionary patterns of various genotypes at different geographical levels. Mutations in the VP1 protein, based on the protein structure of GII.4_Sydney[P31], provided insights into the evolutionary trends of key genotypes. Additionally, recombination analysis identified important breakpoints and fragments for norovirus.
The findings offer valuable insights to evolution and transmission of norovirus. These results can serve as a reference for future research, and they may aid in vaccine development efforts aimed at controlling norovirus outbreaks.
诺如病毒是急性肠胃炎的关键病原体，给经济和公共卫生带来了沉重负担。本研究聚焦于2016年至2022年中国深圳诺如病毒的持续监测，旨在结合全球序列数据背景分析诺如病毒的流行特征和基因多样性。
该研究基于从当地定点医院收集的数据。分析了诺如病毒感染的人口统计学、空间和时间分布。进行了系统发育分析，并在不同地理层面比较了基因型动态。评估了影响蛋白质稳定性的突变，并进行重组分析以确定诺如病毒的关键断点和片段。
研究发现诺如病毒主要感染3岁以下婴幼儿，疫情在冬季发生，且集中在发达地区。系统发育分析揭示了不同地理层面各种基因型进化模式的异同。基于GII.4_Sydney[P31]的蛋白质结构，VP1蛋白中的突变为关键基因型的进化趋势提供了见解。此外，重组分析确定了诺如病毒的重要断点和片段。
这些发现为诺如病毒的进化和传播提供了有价值的见解。这些结果可为未来研究提供参考，并可能有助于旨在控制诺如病毒爆发的疫苗研发工作。
