Robertson M, Boulton F E, Doughty R, MacLennan J R, Collins A, McClelland D B, Prowse C V
Vox Sang. 1985;49(4):259-66. doi: 10.1111/j.1423-0410.1985.tb01120.x.
The formation of macroaggregates weighing up to 9 g was observed in optimal additive red cells. Such aggregates, with a mean wet weight of 3 g, formed progressively during storage and were present in up to 85% of units. They were composed of leucocyte and platelet debris, together with some fibrin. Macroaggregates formation was halved by less stringent centrifugation during preparation and was reduced by use of an optimal additive system in which the additive solution contained citrate. Extra mixing during transfer of the additive solution only delayed aggregate formation. Partial leucocyte depletion or addition of 200,000 KIU of the enzyme inhibitor aprotinin did not prevent macroaggregate formation.
在最佳添加剂红细胞中观察到形成了重达9克的大聚集体。这种平均湿重为3克的聚集体在储存过程中逐渐形成，在高达85%的单位中存在。它们由白细胞和血小板碎片以及一些纤维蛋白组成。在制备过程中通过不太严格的离心可使大聚集体形成减半，并且通过使用添加剂溶液中含有柠檬酸盐的最佳添加剂系统可减少大聚集体形成。在添加剂溶液转移过程中额外混合只会延迟聚集体形成。部分白细胞去除或添加200,000国际单位的酶抑制剂抑肽酶并不能防止大聚集体形成。
