Xu Wenzhe, Xue Yingke, Chen Yang, Yang Ruixu, Liu Shuwei, Liu Yi, Zhang Hao
Plastic and Reconstructive Surgery, The First Hospital of Jilin University, Changchun, 130021, P. R. China.
State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun, 130012, P. R. China.
Adv Sci (Weinh). 2025 Oct;12(37):e03164. doi: 10.1002/advs.202503164. Epub 2025 Jul 3.
Non-symmetric nanoarchitectonics have demonstrated superior performance in nanotherapeutics compared to their symmetric counterparts, particularly in the design of self-propelled nanodrug delivery systems. However, achieving precise morphological control of non-symmetric nanoarchitectonics composed of molecular drugs, without the use of templates and surfactants, remains a significant challenge. In this work, a strategy is presented to construct non-symmetric metal-quinone network (MQN) nanoarchitectonics with controlled morphology and size by manipulating solute and solvent diffusion behaviors during the nanoprecipitation process. The findings reveal that solute diffusion at the liquid-liquid interface of miscible solvent and antisolvent can be confined by self-generated MQNs, which in turn dictates the morphology of the resulting nanoarchitectonics. By regulating interphase solute diffusion kinetics, a variety of MQN nanoarchitectonics are successfully produced with spherical, semifootball-like, and bowl-like morphologies, ranging in sizes from tens to hundred of nanometers. Notably, the non-symmetric MQN nanobowls are further employed to create self-propelled nanodrugs, which indicates enhanced efficacy in tumor therapy. This study underscores the critical role of liquid-liquid interphase solute diffusion in determining the morphology and size of MQN nanoarchitectonics and highlights the potential of nanoprecipitation as a powerful technique for the precise fabrication of non-symmetric nanoarchitectonics.
与对称的纳米结构相比，非对称纳米结构在纳米治疗中已展现出卓越的性能，尤其是在自驱动纳米药物递送系统的设计方面。然而，在不使用模板和表面活性剂的情况下，实现由分子药物组成的非对称纳米结构的精确形态控制仍然是一项重大挑战。在这项工作中，我们提出了一种策略，通过在纳米沉淀过程中操纵溶质和溶剂的扩散行为，构建具有可控形态和尺寸的非对称金属 - 醌网络（MQN）纳米结构。研究结果表明，互溶溶剂和反溶剂的液 - 液界面处的溶质扩散可被自生的MQN限制，这反过来又决定了所得纳米结构的形态。通过调节相间溶质扩散动力学，成功制备了各种形态的MQN纳米结构，包括球形、半足球形和碗形，尺寸范围从几十到几百纳米。值得注意的是，非对称MQN纳米碗进一步用于制备自驱动纳米药物，这表明在肿瘤治疗中疗效增强。这项研究强调了液 - 液相间溶质扩散在决定MQN纳米结构的形态和尺寸方面的关键作用，并突出了纳米沉淀作为精确制造非对称纳米结构的强大技术的潜力。
