This study evaluated the effects of sand- and rice straw ash-derived nanosilicon dioxide (NSis and NSia) on broiler chickens' performance, blood biochemistry, antioxidant status, and tibia bone characteristics. Five hundred forty 10-day-old Arbor Acres male chicks were divided into nine groups, each with six replicates of ten chicks. Diets included a control group without additives, while others were supplemented with sand, rice straw ash, or their nanosilicon derivatives (NSis and NSia) at 300 ppm and 600 ppm. Results indicated significant improvements (P ≤ 0.05) in weight gain and feed conversion ratio in all treatments, with the best outcomes observed in chicks fed diets enriched with NSis or NSia. Blood parameters showed enhanced globulin levels and albumin/globulin ratios. Antioxidant status, assessed by total antioxidant capacity, catalase, and malondialdehyde levels, improved significantly (P ≤ 0.05) with NSis or NSia. Tibia bone characteristics, including width, breaking strength, and bone mineral density and concentration, were also significantly enhanced. No adverse effects on kidney or liver functions or thyroid hormones were observed across all treatments. These findings suggest that enriching broiler diets with sand or rice straw ash-derived nanosilicon dioxide can improve productivity, bone quality, and antioxidant status without any harmful effects.