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电刺激联合电活性生物材料促进周围神经再生的综述

Review on electrical stimulation combined with electroactive biomaterials to promote peripheral nerve regeneration.

作者信息

Song Jiahui, Yuan Zhengchao, Yu Xiao, Shen Yihong, Wu Jinglei, Sun Binbin, Qin Cheng Xue, El-Newehy Mohamed, Mo Xiumei, Gu Hongbing

机构信息

School of Food and Pharmacy, Shanghai Zhongqiao Vocational and Technical University, No. 888 Caolang Road, Jinshan District, Shanghai 201514, P.R. China.

State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Biological Science and Medical Engineering, Donghua University, No. 2999 North Renmin Road, Songjiang District, Shanghai 201620, P.R. China.

出版信息

Burns Trauma. 2025 May 31;13:tkaf039. doi: 10.1093/burnst/tkaf039. eCollection 2025.

DOI:10.1093/burnst/tkaf039
PMID:40625797
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12232428/
Abstract

Peripheral nerve injury results in sensory and motor dysfunction, which is an enormous economic burden for patients and society. Complete recovery of peripheral nerve function after injury is complicated. Utilizing the electrophysiological properties of natural nerves for neuronal regulation and axon regeneration has attracted considerable interest. Electroactive biomaterials induce an active state of electrical stimulation (ES) at the site of peripheral nerve injury when incorporated into nerve guidance channels. Numerous studies have demonstrated that combining ES with electroactive biomaterials can enhance peripheral nerve repair. This review summarizes the regulation of signal pathways by ES and the functions of various electroactive biomaterials, including metals, carbon-based materials, conductive polymers, and piezoelectric materials. Recent advances and research of ES combined with electroactive biomaterials in peripheral nerve repair are reviewed, which may help to come up with more effective strategies to restore neural function after PNI.

摘要

周围神经损伤会导致感觉和运动功能障碍，这对患者和社会来说是巨大的经济负担。损伤后周围神经功能的完全恢复很复杂。利用天然神经的电生理特性进行神经元调节和轴突再生已引起了相当大的关注。当电活性生物材料被整合到神经引导通道中时，它们会在周围神经损伤部位诱导出电刺激（ES） 的激活状态。大量研究表明，将电刺激与电活性生物材料相结合可以增强周围神经修复。本文综述了电刺激对信号通路的调节以及各种电活性生物材料的功能，包括金属、碳基材料、导电聚合物和压电材料。本文还综述了电刺激与电活性生物材料相结合在周围神经修复方面的最新进展和研究，这可能有助于提出更有效的策略来恢复周围神经损伤后的神经功能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f166/12232428/4d74357a727a/tkaf039f11.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f166/12232428/00bb31954121/tkaf039f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f166/12232428/9313f89ec318/tkaf039f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f166/12232428/9813264abe2c/tkaf039f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f166/12232428/bc3e9f6818e7/tkaf039f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f166/12232428/a34ea3b1511b/tkaf039f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f166/12232428/e2c9f18f11b7/tkaf039f10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f166/12232428/4d74357a727a/tkaf039f11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f166/12232428/feb2b88f7231/tkaf039f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f166/12232428/188077fc279d/tkaf039f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f166/12232428/a9824782e60b/tkaf039f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f166/12232428/75400ab56b8f/tkaf039f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f166/12232428/00bb31954121/tkaf039f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f166/12232428/9313f89ec318/tkaf039f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f166/12232428/9813264abe2c/tkaf039f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f166/12232428/bc3e9f6818e7/tkaf039f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f166/12232428/a34ea3b1511b/tkaf039f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f166/12232428/e2c9f18f11b7/tkaf039f10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f166/12232428/4d74357a727a/tkaf039f11.jpg

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