Dewland Thomas A, van Dam Rob M, Marcus Gregory M
Section of Electrophysiology, Division of Cardiology, Department of Medicine, University of California, San Francisco, 505 Parnassus Ave, M-1180B, Box 0124, San Francisco, CA 94143-0124, USA.
Departments of Exercise and Nutrition Sciences and Epidemiology, Milken Institute School of Public Health, The George Washington University, Washington, DC, USA.
Eur Heart J. 2025 Sep 22;46(36):3546-3554. doi: 10.1093/eurheartj/ehaf421.
While rigorous longitudinal study of a widely and enthusiastically consumed dietary substance has it challenges, recent exponential growth in the scientific evaluation of coffee consumption has resulted in a clearer appreciation of the link between this common drink and health outcomes. Coffee has complex effects that can vary between individuals depending on both inherited predispositions as well as consumption habits. Despite the common concern and conventional 'wisdom' that coffee can promote various cardiovascular diseases, the available data suggest that moderate coffee consumption is associated with a reduced risk of hypertension, type 2 diabetes, myocardial infarction, arrhythmias, heart failure, and even overall mortality. Some exceptions have emerged, including the potentially harmful effects of unfiltered coffee with respect to LDL cholesterol and randomized controlled data demonstrating an acute increase in frequency of premature ventricular contractions with coffee consumption. In many instances, the beneficial effects of coffee appear to be independent of caffeine. Given the ubiquity of coffee consumption and the growing prevalence of cardiovascular disease, translating the latest science into accessible knowledge has the capability to tremendously empower patients and impact global health.
尽管对一种被广泛且热烈消费的饮食物质进行严格的纵向研究存在挑战，但近期对咖啡消费的科学评估呈指数级增长，使得人们对这种常见饮品与健康结果之间的联系有了更清晰的认识。咖啡具有复杂的影响，因人而异，这既取决于遗传倾向，也取决于消费习惯。尽管人们普遍担心且传统观念认为咖啡会引发各种心血管疾病，但现有数据表明，适量饮用咖啡与降低高血压、2型糖尿病、心肌梗死、心律失常、心力衰竭甚至总体死亡率的风险相关。也出现了一些例外情况，包括未过滤咖啡对低密度脂蛋白胆固醇可能产生的有害影响，以及随机对照数据表明饮用咖啡会使室性早搏频率急性增加。在许多情况下，咖啡的有益作用似乎与咖啡因无关。鉴于咖啡消费的普遍性以及心血管疾病患病率的不断上升，将最新科学知识转化为通俗易懂的内容能够极大地增强患者的能力，并对全球健康产生影响。
