Kammermeier H, Wein B, Gerards P, Lang U, Wendtland B, Schmitz D, Rose H
Basic Res Cardiol. 1985;80 Suppl 2:89-92.
The capillary wall, due to its diffusional resistance, causes concentration differences between the vascular space and the interstitial space for substances which are released or taken up by the heart. Estimation of capillary transfer and interstitial concentration in isolated hearts, however, indicates a variable diffusional resistance, which in the case of glucose results from an insulin dependent transfer mechanism and in the case of lactate from a dependence of lactate transfer on lactate concentration or direction of transfer. Due to the unpredictable interstitial concentration investigation of sarcolemmal transfer appears to be possible at present only with isolated cardiac myocytes. Sarcolemmal transfer was studied for glucose and lactate. Recent investigations of lactate transfer revealed saturation kinetics, dependence on pyruvate (inhibition at low lactate concentration and enhancement at high lactate concentration) and dependence on pH (linear increase with lowered pH [8.0 to 6.7]).
由于毛细血管壁存在扩散阻力，对于心脏释放或摄取的物质，会导致血管腔隙与间质腔隙之间出现浓度差异。然而，对离体心脏中毛细血管转运和间质浓度的估计表明，扩散阻力存在变化，就葡萄糖而言，这是由胰岛素依赖的转运机制导致的，而就乳酸而言，则是由于乳酸转运依赖于乳酸浓度或转运方向。由于间质浓度不可预测，目前似乎只有利用离体心肌细胞才能对肌膜转运进行研究。对葡萄糖和乳酸的肌膜转运进行了研究。最近对乳酸转运的研究揭示了饱和动力学、对丙酮酸的依赖性（低乳酸浓度时抑制，高乳酸浓度时增强）以及对pH的依赖性（pH从8.0降至6.7时呈线性增加）。
