Kageyama Tatsuto, Seo Jieun, Yan Lei, Hamano Sayuri, Fukuda Junji
Kanagawa Institute of Industrial Science and Technology, 3-2-1 Sakado Takatsu-Ku, Kawasaki, Kanagawa, 213-0012, Japan.
Faculty of Engineering, Yokohama National University, 79-5 Tokiwadai, Hodogaya-Ku, Yokohama, Kanagawa, 240-8501, Japan.
Sci Rep. 2025 Jul 8;15(1):24525. doi: 10.1038/s41598-025-10716-5.
Serotonin (5-hydroxytryptamine, 5-HT) is a neurotransmitter that plays a vital role in regulating behavior, mood, memory, and gastrointestinal homeostasis. Although recent studies have identified an intestine-hair follicle link, potentially implicating 5-HT, its exact relationship with hair growth remains unclear. Here we investigated the effects of serotonin signaling on hair follicle homeostasis. Gene expression analysis showed significant upregulation of hair growth-related genes in dermal papilla cells treated with 5-HT. The hair growth-promoting effects of 5-HT were examined using hair follicle organoids and hair follicle organ cultures. The addition of 5-HT to hair follicle organoids and hair follicles promoted hair shaft elongation. Similar effects were observed with sumatriptan succinate, a 5-HT receptor agonist. These results suggest that targeting serotonin signaling can advance alopecia therapy.
血清素（5-羟色胺，5-HT）是一种神经递质，在调节行为、情绪、记忆和胃肠道内环境稳态方面发挥着至关重要的作用。尽管最近的研究已经确定了肠道与毛囊之间的联系，这可能与5-HT有关，但其与头发生长的确切关系仍不清楚。在这里，我们研究了血清素信号传导对毛囊内环境稳态的影响。基因表达分析表明，用5-HT处理的真皮乳头细胞中与头发生长相关的基因显著上调。使用毛囊类器官和毛囊器官培养物研究了5-HT对头发生长的促进作用。向毛囊类器官和毛囊中添加5-HT可促进毛干伸长。5-HT受体激动剂琥珀酸舒马曲坦也观察到了类似的效果。这些结果表明，针对血清素信号传导可以推进脱发治疗。
