Boucher R C, Pare P D, Gilmore N J, Moroz L A, Hogg J C
J Allergy Clin Immunol. 1977 Aug;60(2):134-40. doi: 10.1016/0091-6749(77)90039-2.
The permeability of the airways to technetium 99m-labeled albumin was measured in Ascaris suum-sensitive rhesus monkeys. All 8 animals were skin-sensitive to Ascaris suum (AA) antigen, 4 being respiratory responders (R) and 4 nonresponders (NR) to aerosolized antigen. In the absence of antigen challenge there were no differences in the accumulation in the blood of radioactive material from the tracheobranchial tree between the R and NR animals. After a five-minute challenge with aerosolized AA, there was a threefold increase in the rate of accumulation of radioactive material in the blood over control for the R group with no effect noted in the NR group. Gel filtration data indicated that the radioactivity in the blood most likely represented low molecular weight albumin fragments, resulting from spontaneous degradation of Tc-albumin, that crossed the mucosa and partially bound to circulating albumin. It is concluded that hyperpermeability of the airway mucosa probably is not a factor that contributes to the selective responsiveness of the R group to aerosolized antigen, and that airway permeability is increased consequent to the allergic reaction mediating acute bronchoconstriction.
在对猪蛔虫敏感的恒河猴中测量气道对99m锝标记白蛋白的通透性。所有8只动物对猪蛔虫（AA）抗原皮肤敏感，其中4只为雾化抗原的呼吸反应者（R），4只为无反应者（NR）。在没有抗原激发的情况下，R组和NR组动物气管支气管树放射性物质在血液中的积累没有差异。在用雾化AA激发五分钟后，R组血液中放射性物质的积累速率比对照组增加了三倍，而NR组未观察到影响。凝胶过滤数据表明，血液中的放射性最可能代表低分子量白蛋白片段，这是由锝白蛋白的自发降解产生的，其穿过粘膜并部分与循环中的白蛋白结合。得出的结论是，气道粘膜的高通透性可能不是导致R组对雾化抗原选择性反应的因素，并且气道通透性因介导急性支气管收缩的过敏反应而增加。
