Zhang Yan, Lin Yuanqing, Galgano Salvatore, Houdijk Jos, Xie Weiquan, Jin Yajie, Lin Jiameng, Song Wuqiang, Fu Yijuan, Li Xiuying, Chui Wenting, Kan Wei, Jia Cai, Hu Guangwei, Li Tao
Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences (CAAS), Shanghai 200241, China.
Animal Disease Prevention and Control Center in Qinghai Province, Xining 810001, China.
Antibiotics (Basel). 2022 Oct 13;11(10):1406. doi: 10.3390/antibiotics11101406.
is a multidrug-resistant and invasive pathogen associated with the etiopathology of both an increasing number of nosocomial infections and is of relevance to poultry production systems. Multidrug-resistant has been reported in connection to severe challenges to clinical treatment, mostly due to an increased rate of resistance to carbapenems. Amid the possible strategies aiming to reduce the insurgence of antimicrobial resistance, phage therapy has gained particular importance for the treatment of bacterial infections. This review summarizes the different phage-therapy approaches currently in use for multiple-drug resistant , including single phage therapy, phage cocktails, phage-antibiotic combination therapy, phage-derived enzymes active on and some novel technologies based on phage interventions. Although phage therapy represents a potential treatment solution for multidrug-resistant , further research is needed to unravel some unanswered questions, especially in regard to its in vivo applications, before possible routine clinical use.
是一种多重耐药且具有侵袭性的病原体，与越来越多的医院感染的病因病理学相关，并且与家禽生产系统有关。已报道多重耐药菌给临床治疗带来严重挑战，主要原因是对碳青霉烯类药物的耐药率增加。在旨在减少抗菌药物耐药性出现的可能策略中，噬菌体疗法在治疗细菌感染方面变得尤为重要。本综述总结了目前用于多重耐药菌的不同噬菌体疗法，包括单一噬菌体疗法、噬菌体鸡尾酒疗法、噬菌体 - 抗生素联合疗法、对[细菌名称未明确给出]有活性的噬菌体衍生酶以及一些基于噬菌体干预的新技术。尽管噬菌体疗法是多重耐药菌的一种潜在治疗方案，但在可能的常规临床应用之前，还需要进一步研究来解决一些未解答的问题，特别是关于其体内应用方面的问题。
