Tucker S B, Flannigan S A
Arch Toxicol. 1983 Nov;54(3):195-202. doi: 10.1007/BF01239203.
The purpose of this study was to determine, through a field survey, the prevalence of cutaneous response to the synthetic pyrethroid fenvalerate; to characterize the cutaneous reaction; and to identify the setting in which it occurs. The methodology involved case studies of selected individuals who had worked extensively with fenvalerate in the delta region of Mississippi and Alabama. All the agricultural workers interviewed and examined had, on some occasion, noted a paresthesia which they associated with exposure to this pyrethroid insecticide. The cutaneous sensation described was a stinging or burning which progressed to numbness in approximately one-third of the exposed workers. The sensation typically began a number of hours after contact, peaked in the evening, and rarely was present the following morning. The intensity of the sensation varied according to the type and extent of exposure. Clinical signs of inflammation such as edema or vesiculation were not apparent. Erythema was present in a limited number of individuals but was not distinguishable from sunburn. Several environmental factors were found to affect the cutaneous sensation associated with fenvalerate exposure.
本研究的目的是通过实地调查确定合成拟除虫菊酯氰戊菊酯引起皮肤反应的发生率；描述皮肤反应特征；并确定其发生的环境。研究方法包括对在密西西比州和阿拉巴马州三角洲地区大量接触氰戊菊酯的选定个体进行案例研究。所有接受访谈和检查的农业工人都曾在某些时候注意到一种感觉异常，他们将其与接触这种拟除虫菊酯杀虫剂联系起来。所描述的皮肤感觉是刺痛或灼痛，约三分之一的接触工人随后会发展为麻木。这种感觉通常在接触数小时后开始，晚上达到高峰，第二天早上很少出现。感觉的强度根据接触的类型和程度而有所不同。炎症的临床体征如水肿或水疱并不明显。少数个体出现红斑，但与晒伤无法区分。发现几个环境因素会影响与氰戊菊酯接触相关的皮肤感觉。
