Schicchi Azzurra, Ruvituso Irene, Petrolini Valeria M, Ferrari Ilaria, Di Pietro Santi, Lonati Davide, Roda Elisa, Valli Antonella, Malovini Alberto L, Perlini Stefano, Locatelli Carlo A, Salinaro Francesco
Pavia Poison Control Centre National Toxicology Information Centre, Clinical and Experimental Lab, Toxicology Unit, Istituti Clinici Scientifici Maugeri IRCCS, Via Salvatore Maugeri, 10, 27100, Pavia, Italy.
Experimental Medicine PhD Program, University of Pavia, Pavia, Italy.
Intern Emerg Med. 2025 Jul 9. doi: 10.1007/s11739-025-04040-z.
In Italy, deliberate self-poisoning (DSP) represents a significant proportion of emergency department (ED) admissions for acute poisoning. This study examines the impact of the COVID-19 pandemic on the incidence, characteristics, and management of DSP in adults in Pavia, a region of Italy heavily affected during the initial outbreak. We conducted a retrospective observational study of DSP cases managed at the ED of IRCCS San Matteo Foundation University Hospital for which the advice of the Pavia Poison Control Centre (PPCC) was requested (January 1, 2019-December 31, 2022). Data were collected from the PPCC and ED electronic health records. We analyzed trends in DSPs in relation to Italian government-imposed COVID-19 restrictions. We included 324 cases, the 74.7% had a history of psychiatric disease. The trends in DSPs changed in relation to the phases of the COVID-19 pandemic. The number of DSPs increased during lockdown 2. A significant increase in DSPs has been found in patients with no prior history of psychiatric illness before COVID. The most used substances were drugs, covering 84.3% of all included cases with neuropsychotropic drugs as the most frequently used (222/273, 81.3%). The COVID-19 pandemic had an impact on DSP trends in the adult population, with an increase in cases among individuals without prior psychiatric history. The persistence of DSP cases throughout 2022 suggests that the psychological toll of the pandemic may have long-term consequences in the Pavia area, Italy. Future studies should aim to explore the long-term effects of the pandemic on mental health and suicidal behavior.
在意大利，蓄意自我中毒（DSP）在急性中毒的急诊科（ED）入院病例中占很大比例。本研究考察了新冠疫情对意大利帕维亚地区成年人DSP的发病率、特征及管理的影响，帕维亚是在疫情初期受严重影响的一个地区。我们对IRCCS圣马泰奥基金会大学医院急诊科处理的DSP病例进行了一项回顾性观察研究，这些病例曾寻求帕维亚中毒控制中心（PPCC）的建议（2019年1月1日至2022年12月31日）。数据从PPCC和急诊科电子健康记录中收集。我们分析了与意大利政府实施的新冠疫情限制措施相关的DSP趋势。我们纳入了324例病例，其中74.7%有精神疾病史。DSP的趋势随新冠疫情的阶段而变化。在第二次封锁期间DSP病例数增加。在新冠疫情之前无精神疾病史的患者中，DSP病例数显著增加。最常使用的物质是药物，在所有纳入病例中占84.3%，其中神经精神药物使用最为频繁（222/273，81.3%）。新冠疫情对成年人群体的DSP趋势产生了影响，无精神疾病史个体中的病例数有所增加。2022年全年DSP病例持续存在，这表明疫情带来的心理负担可能在意大利帕维亚地区产生长期后果。未来的研究应旨在探索疫情对心理健康和自杀行为的长期影响。
