Siefried Krista J, Hill Penny, Clifford Brendan, Brown Jared, Camilleri Andrew, Crawford Sione, Dessauer Paul, Dilkes-Frayne Ella, Freestone Jack, Gobeil John, Harrod Mary E, Hudson Suzie, Hull Philip, Lenton Simon, Lyons Tom, Oh Grace, Peacock Amy, Pierce Alice, Sidaway Peter, Soderstrom Jessamine, Tzanetis Stephanie, Ezard Nadine
The National Centre for Clinical Research on Emerging Drugs, The University of New South Wales, Sydney, NSW, Australia.
St Vincent's Hospital Alcohol and Drug Service, Darlinghurst, NSW, Australia.
Front Public Health. 2025 Jun 25;13:1521911. doi: 10.3389/fpubh.2025.1521911. eCollection 2025.
The rapid emergence of new psychoactive substances (NPS) and other emerging drugs of concern presents a significant global public health challenge, necessitating agile and interconnected drug information systems to identify and communicate risks. In Australia, responses have traditionally been localized, lacking a nationally coordinated system to rapidly share information about emerging drug threats. The National Center for Clinical Research on Emerging Drugs (NCCRED) collaborated with jurisdictional networks, clinicians, scientists, policy-makers, and peer organizations to co-design and co-produce the national Prompt Response Network ("PRN"). This process identified key components necessary to create an effective health-focused national network that supports and enhances existing and emerging jurisdictional and specialist early warning networks. The co-creation process resulted in several outputs, including a formalized national PRN group, an online knowledge exchange platform, a national website for disseminating drug alerts, and identified needs for a national drug signal database and an anecdotal reporting system. The PRN is the first Australian national public-health-focused mechanism for information exchange on new and emerging drugs and drug trends of concern. It provides the means for timely and responsive sharing of localized data, better informing risk assessment and facilitating a coordinated approach to public health responses and local and national preparation for emerging risks. Achieving this required mobilizing diverse disciplinary and community stakeholders toward a unified and collaborative response to preventing drug related harms.
新型精神活性物质（NPS）及其他新兴受关注药物的迅速出现给全球公共卫生带来了重大挑战，因此需要灵活且相互关联的药物信息系统来识别并传达风险。在澳大利亚，以往的应对措施多为本地化的，缺乏一个全国协调的系统来迅速共享有关新兴药物威胁的信息。国家新兴药物临床研究中心（NCCRED）与各辖区网络、临床医生、科学家、政策制定者及同行组织合作，共同设计并创建了国家快速反应网络（“PRN”）。这一过程确定了创建一个有效的以健康为重点的全国性网络所需的关键要素，该网络可支持并加强现有的及新兴的辖区和专业预警网络。共同创建过程产生了多项成果，包括一个正式的全国PRN小组、一个在线知识交流平台、一个用于发布药物警报的国家网站，并确定了对国家药物信号数据库和轶事报告系统的需求。PRN是澳大利亚首个以公共卫生为重点的关于新型和新兴药物以及受关注药物趋势的信息交流机制。它为及时且有针对性地共享本地化数据提供了途径，能更好地为风险评估提供信息，并促进采取协调一致的方法来应对公共卫生问题以及为应对新兴风险进行地方和国家层面的准备。实现这一点需要动员不同学科和社区的利益相关者，以采取统一协作的应对措施来预防与药物相关的危害。
