Karlin D A, McBath M, Jones R D, Elwyn K E, Romsdahl M M
Cancer Lett. 1985 Oct;29(1):73-8. doi: 10.1016/0304-3835(85)90125-9.
Our objective was to determine whether chronic hypergastrinemia enhances chemical induction of rat colorectal cancers. Forty-five rats were randomized to sham operation or antral exclusion. Following a 2-week postoperative recovery period all rats were treated with 1,2-dimethylhydrazine (10 mg/kg) intraperitoneally for 20 weekly doses. Seven weeks later, the rats were killed. Blood was assayed for gastrin by radioimmunoassay. Tumor number, location, size, weight and histology were determined. The 23 rats receiving antral exclusion were hypergastrinemic compared with the 22 sham operated rats. All hypergastrinemic rats developed tumors while only 72.7% of normogastrinemic rats developed tumors. Hypergastrinemia increased the number of tumors/rat, total tumor weight/rat and total tumor volume/rat.
我们的目的是确定慢性高胃泌素血症是否会增强大鼠结直肠癌的化学诱导作用。45只大鼠被随机分为假手术组或胃窦切除术组。术后2周恢复期后，所有大鼠均腹腔注射1,2 - 二甲基肼（10 mg/kg），每周注射20次。7周后，处死大鼠。通过放射免疫分析法检测血液中的胃泌素。确定肿瘤的数量、位置、大小、重量和组织学类型。与22只接受假手术的大鼠相比，23只接受胃窦切除术的大鼠出现了高胃泌素血症。所有高胃泌素血症大鼠都发生了肿瘤，而正常胃泌素血症大鼠中只有72.7%发生了肿瘤。高胃泌素血症增加了每只大鼠的肿瘤数量、每只大鼠的肿瘤总重量和每只大鼠的肿瘤总体积。
