Piersma A H, Ploemacher R E, Brockbank K G, Nikkels P G, Ottenheim C P
Cell Tissue Kinet. 1985 Nov;18(6):589-95. doi: 10.1111/j.1365-2184.1985.tb00702.x.
This paper describes the kinetics of fibroblastic colony forming units (CFU-f) in murine blood after phenylhydrazine-induced haemolytic anaemia and their subsequent migration into haemopoietic organs. Murine blood contained 5.3 +/- 0.8 CFU-f per 10(6) nucleated cells. Absence of particle ingestion and factor VIII-related antigen in addition to the enzyme pattern in CFU-f-derived cells confirmed that these cells did not have a macrophage-like or endothelial nature. Phenylhydrazine treatment of mice resulted in a 3-fold increase in blood CFU-f numbers which was accompanied by increases in blood cellularity and granulocyte-macrophage progenitor numbers. When both partners of CBA/N and CBA/T6T6 mice in parabiosis had been treated with phenylhydrazine, spleens and femoral bone marrow of both mice were shown to contain partner-derived CFU-f. These data suggest that circulating CFU-f represent a stromal cell population which can migrate into haemopoietic organs.
本文描述了苯肼诱导的溶血性贫血后小鼠血液中成纤维细胞集落形成单位（CFU-f）的动力学及其随后向造血器官的迁移。每10⁶个有核细胞中，小鼠血液含5.3±0.8个CFU-f。CFU-f衍生细胞除了酶模式外，不存在颗粒摄取和因子VIII相关抗原，这证实这些细胞不具有巨噬细胞样或内皮细胞性质。用苯肼处理小鼠导致血液CFU-f数量增加3倍，同时伴有血细胞数量和粒细胞-巨噬细胞祖细胞数量增加。当联体生活的CBA/N和CBA/T6T6小鼠双方都用苯肼处理后，两只小鼠的脾脏和股骨骨髓都显示含有来自对方的CFU-f。这些数据表明，循环中的CFU-f代表了一种能够迁移到造血器官的基质细胞群体。
