Gaggino Andrea, Inferrera Leandro, Milan Serena, Presotto Marianna, Tognetto Daniele
Eye Clinic, Department of Medical, Surgical Sciences and Health, University of Trieste, Trieste, Italy.
Case Rep Ophthalmol. 2025 Feb 19;16(1):182-193. doi: 10.1159/000543643. eCollection 2025 Jan-Dec.
The aim of this study was to report the cases of 6 patients with the coexistence of polypoidal choroidal vasculopathy (PCV) and choroidal nevi.
Six patients with the coexistence of PCV and choroidal nevi were thoroughly evaluated by slit-lamp biomicroscopy examination, color fundus photography, optical coherence tomography (OCT), OCT angiography (OCT-A), fluorescein angiography (FA), indocyanine green angiography (ICG-A), fundus blue autofluorescence (BAF), and ocular ultrasound (OU). The typical features of PCV and nevi were present in all patients, three of whom were treated with intravitreal anti-angiogenic agents. In each clinical case, the choroidal Haller's vessels adjacent to the nevus were visibly more dilated compared to normal. Color fundus photography, OCT, OCT-A, FA, ICG-A, BAF, and OU revealed similar findings across all cases. Observations revealed that choroidal nevi could instigate modifications in the outer retina, resulting in persistent alterations capable of triggering the formation of neovascularization.
The occurrence of a PCV alongside nevus is an uncommon complication. Findings from all exams performed were consistent across all cases, highlighting the potential link between PCV and nevi.
本研究的目的是报告6例息肉样脉络膜血管病变（PCV）与脉络膜痣并存的病例。
对6例PCV与脉络膜痣并存的患者进行了全面评估，包括裂隙灯生物显微镜检查、彩色眼底照相、光学相干断层扫描（OCT）、OCT血管造影（OCT-A）、荧光素血管造影（FA）、吲哚菁绿血管造影（ICG-A）、眼底自发荧光（BAF）和眼部超声（OU）。所有患者均具有PCV和痣的典型特征，其中3例接受了玻璃体内抗血管生成药物治疗。在每个临床病例中，与痣相邻的脉络膜哈勒氏血管明显比正常情况下更扩张。彩色眼底照相、OCT、OCT-A、FA、ICG-A、BAF和OU在所有病例中均显示出相似的结果。观察结果显示，脉络膜痣可引发视网膜外层的改变，导致持续变化，进而引发新生血管形成。
PCV与痣并存是一种罕见的并发症。所有检查结果在所有病例中均一致，突出了PCV与痣之间的潜在联系。
