Lan Xiaodong, Tang Yong, Huang Zhenjia, Zhou Tao, Wang Chao, Ma Yan, Li Dan, Huang Zhiyong, Huang Yuesheng
Department of Burn and Plastic Surgery, Chengdu Second People's Hospital, Chengdu, China.
Institute of Wound Repair and Regeneration Medicine, Southern University of Science and Technology School of Medicine, Shenzhen, China.
Wound Repair Regen. 2025 Jul-Aug;33(4):e70064. doi: 10.1111/wrr.70064.
Pressure ulcers (PUs) are chronic wounds that pose a significant burden on patients, families, and healthcare systems worldwide. This study evaluates the prevalence, trends, and burden of PUs to inform targeted public health policies. Using data from the Global Burden of Disease (GBD) Study 2021, we analysed PU incidence, mortality, and disability-adjusted life years (DALYs) across 204 countries from 1990 to 2021. Trends were assessed using the estimated annual percentage change (EAPC) in age-standardised rates (ASRs), and future projections were made using the ARIMA model. Globally, PU incident cases increased from 1,142,594.8 in 1990 to 2,468,317.5 in 2021. The ASIR showed a slight decrease, from 31.5 to 30.3 per 100,000. The mortality rose from 16,741.1 to 37,032.7, while the ASMR exhibited numerical stability (0.5 per 100,000). The DALYs increased from 408,887.0 in 1990 to 803,747.4 in 2021, with a decline in ASDR, from 10.7 to 9.7 per 100,000. Absolute numbers, ASRs, and EAPCs exhibit a pronounced correlation with the SDI. Moreover, there exist notable disparities across different regions or nations. The burden of PU was notably higher in elderly females, though the increase among the elderly males was also significant. Projections for 2022-2031 indicate a slight decrease in both ASIR and ASMR, while ASDR is expected to rise. While PU incidence remains high, disparities persist, especially in low-SDI regions. Strengthening prevention strategies and improving healthcare access are critical to reducing the global PU burden.
压疮是一种慢性伤口，给全球范围内的患者、家庭和医疗系统带来了沉重负担。本研究评估压疮的患病率、趋势和负担，以为针对性的公共卫生政策提供依据。利用《2021年全球疾病负担研究》的数据，我们分析了1990年至2021年期间204个国家的压疮发病率、死亡率和伤残调整生命年（DALYs）。使用年龄标准化率（ASRs）的估计年度百分比变化（EAPC）评估趋势，并使用自回归积分移动平均（ARIMA）模型进行未来预测。全球范围内，压疮发病病例从1990年的1,142,594.8例增加到2021年的2,468,317.5例。年龄标准化发病率（ASIR）略有下降，从每10万人31.5例降至30.3例。死亡率从16,741.1例上升至37,032.7例，而年龄标准化死亡率（ASMR）保持稳定（每10万人0.5例）。伤残调整生命年从1990年的408,887.0增加到2021年的803,747.4，年龄标准化伤残调整率（ASDR）从每10万人10.7例降至9.7例。绝对数、年龄标准化率和估计年度百分比变化与社会人口指数（SDI）呈现出显著相关性。此外，不同地区或国家之间存在明显差异。老年女性的压疮负担明显更高，不过老年男性的负担增加也较为显著。2022年至2031年的预测表明，年龄标准化发病率和年龄标准化死亡率均略有下降，而年龄标准化伤残调整率预计将上升。虽然压疮发病率仍然很高，但差异依然存在，尤其是在低社会人口指数地区。加强预防策略和改善医疗服务可及性对于减轻全球压疮负担至关重要。
