Ramos Natalia, Jones Skylar, Zhang Lily, Nuño Miriam, Ramsey Benita, Ceseña Dannie, Mireles Alyssa, Wells Kenneth
Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.
Research Center for Health Services and Society, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, United States.
JMIR Form Res. 2025 Jul 11;9:e67082. doi: 10.2196/67082.
Lesbian, gay, bisexual, transgender, queer, and questioning (LGBTQ+) individuals faced greater mental health challenges during the COVID-19 pandemic than binary-gender heterosexual (non-LGBTQ+) adults. The Together for Wellness/Juntos por Nuestro Bienestar website with free well-being resources, developed during the COVID-19 pandemic with partner input, included LGBTQ+ resources. A pilot evaluation among adults (aged ≥18 years) found engagement with and use of the website 4 to 6 weeks before follow-up was associated with reduced (pretest-posttest) depression. Results for LGBTQ+ participants were not reported.
This study describes baseline depression, anxiety, and website engagement for LGBTQ+ compared with non-LGBTQ+ adults and pretest-posttest changes in depression and anxiety (the primary outcome).
Community partners invited health and social services providers, clients, and partners to visit the website and complete a survey app (Chorus Innovations) at baseline (September 20, 2021-April 4, 2022) and a 4- to 6-week follow-up (October 22, 2021-May 17, 2022). LGBTQ+ adults were compared to non-LGBTQ+ adults in demographics, website use, depression, and anxiety. Sensitivity analyses were adjusted for nonresponse (inverse probability weighting). Regression analyses identified predictors for reduction (pretest-posttest) in depression (2-item Patient Health Questionnaire [PHQ-2]) and anxiety (2-item Generalized Anxiety Disorder scale [GAD-2]).
Of 315 adults who completed the baseline survey and 193 who completed the follow-up survey, 64 (20.3%) and 37 (19.2%), respectively, were LGBTQ+. At baseline, LGBTQ+ compared to non-LGBTQ+ adults had higher scores on the PHQ-2 (mean 2.4, SD 1.7 vs 1.3, SD 1.3; t=5.31; P<.001) and GAD-2 (mean 2.7, SD 1.7 vs 1.6, SD 1.5; t=4.96; P<.001) and more COVID-19 stressors (mean score 8.1, SD 4.4 vs 6.5, SD 4.0; t=2.8; P=.003). Before follow-up, LGBTQ+ adults had similar website use (P=.65) and likelihood to recommend the website to others (P=.26) compared to non-LGBTQ+ adults. LGBTQ+ adults had more reduction (pretest-posttest) in mean GAD-2 scores (-0.8, SD 2.0 vs 0.0, SD 1.2; t=-3.08; P=.002) and mean PHQ-2 scores (-0.7, SD 1.7 vs -0.1, SD 1.4; t=-2.16; P=.03) compared to non-LGBTQ+ adults. For LGBTQ+ adults, predictors of pretest-posttest decline (adjusting for nonresponse) in mean GAD-2 scores included visiting the website and using resources 4 to 6 weeks before (β=-1.95, 95% CI -3.20 to -0.70; P=.003); for decline in mean PHQ-2, visiting website/using resources had a trend as predictor that was not significant adjusting for nonresponse (β=-.94 (-2.00, 0.013), P=.09).
LGBTQ+ adults reported higher baseline depression, anxiety, and COVID-19 stressors than non-LGBTQ+ adults. Among LGBTQ+ but not among non-LGBTQ+ adults, higher website use was associated with reduced anxiety over time. Findings suggest that online resources may promote well-being for LGBTQ+ adults in pandemics.
女同性恋、男同性恋、双性恋、跨性别、酷儿及性取向存疑(LGBTQ+)群体在新冠疫情期间面临的心理健康挑战比二元性别异性恋(非LGBTQ+)成年人更大。“共同促进健康/携手共创福祉”网站在新冠疫情期间根据合作伙伴的意见开发,提供免费的健康资源,其中包括LGBTQ+相关资源。一项针对成年人(年龄≥18岁)的试点评估发现,在随访前4至6周参与并使用该网站与抑郁症状减轻(前后测对比)相关。未报告LGBTQ+参与者的结果。
本研究描述了LGBTQ+成年人与非LGBTQ+成年人相比的基线抑郁、焦虑情况以及网站参与度,以及抑郁和焦虑的前后测变化(主要结局)。
社区合作伙伴邀请健康和社会服务提供者、服务对象及其伴侣在基线期(2021年9月20日至2022年4月4日)访问该网站并完成一项调查应用程序(Chorus Innovations),并在4至6周后进行随访(2021年10月22日至2022年5月17日)。比较了LGBTQ+成年人与非LGBTQ+成年人在人口统计学特征、网站使用情况、抑郁和焦虑方面的差异。敏感性分析针对无应答情况进行了调整(逆概率加权)。回归分析确定了抑郁(2项患者健康问卷[PHQ-2])和焦虑(2项广泛性焦虑障碍量表[GAD-2])减轻(前后测对比)的预测因素。
在完成基线调查的315名成年人和完成随访调查的193名成年人中,分别有64名(20.3%)和37名(19.2%)为LGBTQ+群体。在基线期,与非LGBTQ+成年人相比,LGBTQ+成年人的PHQ-2得分更高(均值2.4,标准差1.7 vs 1.