Ferland Marie-Chantal, Wang Ruiqi, Therrien-Blanchet Jean-Marc, Remahi Sarah, Côté Samantha, Fréchette Ann-Jessica, Dang-Vu Thien Thanh, Liu Hesheng, Lepage Jean-François, Théoret Hugo
Department of Psychology, Faculté des Arts et Sciences, Université de Montréal, Montréal, Canada.
Changping Laboratory & Peking University, Beijing, China.
Brain Imaging Behav. 2025 Jul 12. doi: 10.1007/s11682-025-01043-4.
Lorazepam is a fast-acting benzodiazepine that is widely used to manage anxiety symptoms through modulation of GABAergic activity. Despite being one of the most prescribed benzodiazepines, the effects of a single dose of lorazepam on brain functional connectivity at rest is not known. In this placebo-controlled, crossover study, twenty healthy adult participants (9 women; 26.2 ± 5.2 years) underwent two resting-state fMRI (rs-fMRI) scans following administration of either lorazepam (2.5 mg) or placebo. Imaging data were analyzed using an individual brain network parcellation approach and differences in functional connectivity among 78 individual-specific ROIs were estimated. Compared to placebo, functional connectivity was reduced following administration of lorazepam between the left medial paracentral lobule and left temporal pole and between the left posterior cingulate sulcus and right cuneus. Reduced connectivity within higher-order cognitive networks partly supports what has been reported for other benzodiazepines such as midazolam and alprazolam. However, differences across benzodiazepines - possibly due to pharmacokinetics, dosage and receptor selectivity - underscore the need for further research.
劳拉西泮是一种起效迅速的苯二氮䓬类药物，通过调节γ-氨基丁酸（GABA）能活性广泛用于管理焦虑症状。尽管是最常被处方的苯二氮䓬类药物之一，但单剂量劳拉西泮对静息状态下脑功能连接的影响尚不清楚。在这项安慰剂对照的交叉研究中，20名健康成年参与者（9名女性；26.2±5.2岁）在服用劳拉西泮（2.5毫克）或安慰剂后接受了两次静息态功能磁共振成像（rs-fMRI）扫描。使用个体脑网络分割方法分析成像数据，并估计78个个体特异性感兴趣区域（ROI）之间功能连接的差异。与安慰剂相比，服用劳拉西泮后，左侧中央旁小叶内侧与左侧颞极之间以及左侧扣带回后沟与右侧楔叶之间的功能连接减少。高阶认知网络内连接性降低部分支持了其他苯二氮䓬类药物如咪达唑仑和阿普唑仑的相关报道。然而，不同苯二氮䓬类药物之间的差异——可能由于药代动力学、剂量和受体选择性——强调了进一步研究的必要性。
