Benetti Eleonora, Mirra Alessandro, Levionnois Olivier Louis
Anaesthesiology and Pain Therapy Section, Department of Clinical Veterinary Medicine, Vetsuisse Faculty, University of Bern, 3012 Bern, Switzerland.
Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Montreal, Saint-Hyacinthe, QC J2S 8H5, Canada.
Animals (Basel). 2025 Jun 23;15(13):1854. doi: 10.3390/ani15131854.
Neuromuscular blocking agents such as atracurium and rocuronium are commonly used during anesthetic procedures in laboratory pigs. However, species-specific dosing guidelines remain limited, leading to reliance on data extrapolated from other species. This prospective, blinded study aimed to determine the equipotent dose for atracurium (A) and rocuronium (R) in laboratory pigs receiving propofol and to compare their cost-effectiveness. Twelve healthy animals were randomly distributed according to the drug administered ( = 6 per group). For both drugs, the infusion rate was adjusted following an up-and-down titration to maintain a train-of-four count between 3 and 4. Group differences were analyzed using the Wilcoxon signed-rank test. The bolus induction dose (mg/kg) was comparable between atracurium (2.3 [1.8-2.6]) and rocuronium (2 [2]), while atracurium was associated with higher costs (CHF/kg: A, 1.122 [0.878-1.366] versus R, 0.208 [0.208-0.208]; = 0.002725). The maintenance infusion rate (mg/kg/h) was approximately 40% lower for atracurium (2.7 [2.5-2.8]) than for rocuronium (4.5 [4.4-4.5]; = 0.004922), yet the maintenance cost (CFH/kg/h) remained higher for atracurium (A: 1.30 [1.22-1.37] versus R: 0.47 [0.45-0.47]; = 0.0043). This study reports higher doses for anesthetized pigs compared to other species and demonstrates that rocuronium offers superior cost-effectiveness compared to atracurium under these experimental conditions.
在实验室猪的麻醉过程中，常用阿曲库铵和罗库溴铵等神经肌肉阻滞剂。然而，针对特定物种的给药指南仍然有限，导致依赖从其他物种推断的数据。这项前瞻性、双盲研究旨在确定接受丙泊酚的实验室猪中阿曲库铵（A）和罗库溴铵（R）的等效剂量，并比较它们的成本效益。12只健康动物根据给药药物随机分配（每组 = 6只）。对于两种药物，均采用上下滴定法调整输注速率，以维持四个成串刺激计数在3至4之间。使用Wilcoxon符号秩检验分析组间差异。阿曲库铵（2.3 [1.8 - 2.6]）和罗库溴铵（2 [2]）之间的推注诱导剂量（mg/kg）相当，而阿曲库铵的成本更高（瑞士法郎/千克：A，1.122 [0.878 - 1.366] 对比 R，0.208 [0.208 - 0.208]； = 0.002725）。阿曲库铵的维持输注速率（mg/kg/h）（2.7 [2.5 - 2.8]）比罗库溴铵（4.5 [4.4 - 4.5]）低约40%（ = 0.004922），但阿曲库铵的维持成本（瑞士法郎/千克/小时）仍然更高（A：1.30 [1.22 - 1.37] 对比 R：0.47 [由0.45 - 0.47]； = 0.0043）。本研究报告的麻醉猪剂量高于其他物种，并表明在这些实验条件下，罗库溴铵比阿曲库铵具有更高的成本效益。
