Szczuko Małgorzata, Szabunia Natalia, Radkiewicz Julia, Jamioł-Milc Dominika, Machałowski Tomasz, Ziętek Maciej
Department of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, 70-204 Szczecin, Poland.
Department of Bromatology and Nutritional Diagnostic, Pomeranian Medical University in Szczecin, 70-204 Szczecin, Poland.
Int J Mol Sci. 2025 Jul 3;26(13):6424. doi: 10.3390/ijms26136424.
Short-chain fatty acids (SCFAs) are involved in metabolism and physiological processes. We decided to investigate whether SCFAs are engaged in the metabolic programming of the offspring by the mother's microbiota, which interact during pregnancy, delivery, and breastfeeding. We decided to determine whether there are correlations between 4-week-old infant feces SCFA concentrations, their weight at birth, and mothers' anthropometric measurements. The study included 82 women with four-week-old newborns from whom stools were collected. SCFAs were determined using gas chromatography with a flame ionization detector. Correlations were observed between SCFA content in newborns' feces and mothers' weight and body mass index (BMI) before delivery and at the time of delivery. In addition, associations were identified between weight gain of pregnant women and SCFAs. Analysis of neonatal data showed associations between fatty acid content and infants' weight and diet, including breastfeeding. We provide indirect evidence for the association of infant SCFA levels with metabolic programming by maternal gut microbiota metabolites. At the same time, we confirm the influence of increased SCFA levels on higher maternal and neonatal body weight and branched-chain short-chain fatty acids (BCFAs) on neonatal body weight. We provide new preventive and intervention directions for future efforts to improve the health care of pregnant women and their offspring.
短链脂肪酸（SCFAs）参与新陈代谢和生理过程。我们决定研究短链脂肪酸是否通过母亲的微生物群参与后代的代谢编程，这些微生物群在怀孕、分娩和母乳喂养期间相互作用。我们决定确定4周龄婴儿粪便中短链脂肪酸浓度、其出生体重与母亲人体测量指标之间是否存在相关性。该研究纳入了82名有4周龄新生儿的女性，并收集了她们的粪便。使用带有火焰离子化检测器的气相色谱法测定短链脂肪酸。观察到新生儿粪便中短链脂肪酸含量与母亲分娩前及分娩时的体重和体重指数（BMI）之间存在相关性。此外，还发现孕妇体重增加与短链脂肪酸之间存在关联。对新生儿数据的分析表明，脂肪酸含量与婴儿体重和饮食（包括母乳喂养）之间存在关联。我们为婴儿短链脂肪酸水平与母体肠道微生物群代谢产物的代谢编程之间的关联提供了间接证据。同时，我们证实了短链脂肪酸水平升高对母亲和新生儿较高体重的影响，以及支链短链脂肪酸（BCFAs）对新生儿体重的影响。我们为未来改善孕妇及其后代医疗保健的努力提供了新的预防和干预方向。
