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用于太空探索的合成生物学。

Synthetic biology for space exploration.

作者信息

Onofri Silvano, Moeller Ralf, Billi Daniela, Balsamo Michele, Becker Anke, Benvenuto Eugenio, Cassaro Alessia, Catanzaro Ilaria, Cockell Charles S, Desiderio Angiola, Ellis Tom, Gonzáles-Pastor José Eduardo, Hahn Christiane, Leys Natalie, Leo Patrick, Maurel Marie-Christine, Pacelli Claudia, Pavletic Bruno, Ripa Caterina, Rothschild Lynn J, Surdo Leonardo

机构信息

Department of Ecological and Biological Sciences, University of Tuscia, Viterbo, Italy.

German Aerospace Center (DLR e.V.), Institute of Aerospace Medicine, Radiation Biology Department, Linder Hoehe, Cologne/Köln, Germany.

出版信息

NPJ Microgravity. 2025 Jul 12;11(1):41. doi: 10.1038/s41526-025-00488-7.

DOI:10.1038/s41526-025-00488-7
PMID:40651964
Abstract

Human space exploration faces different challenges. Topics like Bioregenerative Life Support Systems, In Situ Resource Utilization, and radiation protection, still require for more suitable solutions to be applied in long-term space exploration. Synthetic biology could be a powerful tool for enabling human exploration of space and planets. This paper explores key topics including resource utilization, life support systems, radiation protection, and human health, providing recommendations for short-, mid-, and long-term advancements in space exploration.

摘要

人类太空探索面临着不同的挑战。诸如生物再生生命支持系统、原位资源利用和辐射防护等主题,仍需要更合适的解决方案应用于长期太空探索。合成生物学可能是助力人类探索太空和其他星球的有力工具。本文探讨了包括资源利用、生命支持系统、辐射防护和人类健康等关键主题,为太空探索在短期、中期和长期的发展提供了建议。

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本文引用的文献

1
Plant and microbial science and technology as cornerstones to Bioregenerative Life Support Systems in space.植物与微生物科学技术是太空生物再生生命保障系统的基石。
NPJ Microgravity. 2023 Aug 24;9(1):69. doi: 10.1038/s41526-023-00317-9.
2
as a cell factory for the production of pyomelanin, a molecule with UV-C radiation shielding activity.作为生产焦黑素的细胞工厂,焦黑素是一种具有紫外线C辐射屏蔽活性的分子。
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Microbial applications for sustainable space exploration beyond low Earth orbit.
用于低地球轨道以外可持续太空探索的微生物应用。
NPJ Microgravity. 2023 Jun 21;9(1):47. doi: 10.1038/s41526-023-00285-0.
4
Filamentous fungi for sustainable remediation of pharmaceutical compounds, heavy metal and oil hydrocarbons.丝状真菌用于药物化合物、重金属和石油烃的可持续修复。
Front Bioeng Biotechnol. 2023 Feb 14;11:1106973. doi: 10.3389/fbioe.2023.1106973. eCollection 2023.
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Towards sustainable human space exploration-priorities for radiation research to quantify and mitigate radiation risks.迈向可持续的人类太空探索——辐射研究的优先事项,以量化和减轻辐射风险。
NPJ Microgravity. 2023 Jan 27;9(1):8. doi: 10.1038/s41526-023-00262-7.
6
Design of a modular controlled unit for the study of bioprocesses: Towards solutions for Bioregenerative Life Support Systems in space.用于生物工艺研究的模块化控制单元设计:为太空生物再生生命支持系统提供解决方案。
Life Sci Space Res (Amst). 2023 Feb;36:8-17. doi: 10.1016/j.lssr.2022.10.006. Epub 2022 Oct 28.
7
Harnessing bioengineered microbes as a versatile platform for space nutrition.利用生物工程微生物作为太空营养的多功能平台。
Nat Commun. 2022 Oct 19;13(1):6177. doi: 10.1038/s41467-022-33974-7.
8
Evolution of increased complexity and specificity at the dawn of form I Rubiscos.形式 I Rubisco 出现之初,复杂性和特异性增加的进化。
Science. 2022 Oct 14;378(6616):155-160. doi: 10.1126/science.abq1416. Epub 2022 Oct 13.
9
Biosignature stability in space enables their use for life detection on Mars.生物特征在太空中的稳定性使其可用于火星上的生命探测。
Sci Adv. 2022 Sep 9;8(36):eabn7412. doi: 10.1126/sciadv.abn7412. Epub 2022 Sep 7.
10
Cultivation of the Dematiaceous Fungus Aboard the International Space Station and Effects of Ionizing Radiation.国际空间站上暗色丝孢真菌的培养及电离辐射的影响
Front Microbiol. 2022 Jul 5;13:877625. doi: 10.3389/fmicb.2022.877625. eCollection 2022.