咖啡和咖啡因摄入量与慢性肾脏病之间的关联
Association between coffee and caffeine consumption and chronic kidney disease.
作者信息
Gao Panpan, Ji Xinrong, Wang Weiwei, Chen Yao, Gao Zhan, Yu Zengli
机构信息
The Third Hospital affiliated Zhengzhou University, Zhengzhou, China.
The Fifth Hospital affiliated Zhengzhou University, Zhengzhou, China.
出版信息
Sci Rep. 2025 Jul 12;15(1):25228. doi: 10.1038/s41598-025-11543-4.
Chronic kidney disease (CKD) is a significant global health issue associated with cardiovascular complications. While coffee, tea, and caffeine consumption have been linked to various health benefits, their relationship with CKD remains unclear. We conducted a cross-sectional analysis of NHANES 1999-2018 data, including 49,827 participants, assessing dietary intake through two 24-hour recalls and determining CKD status via the CKD-EPI equation. Our results showed that after adjusting for covariates, higher coffee consumption (> 352.5 g/day) was associated with lower odds of CKD (OR 0.760, 95% CI 0.701-0.823), as was tea consumption (OR 0.913, 95% CI 0.843-0.89). The highest tertile of caffeine consumption also showed a significantly reduced odds of CKD (OR 0.734, 95% CI 0.674-0.799). These findings suggest that coffee, tea, and caffeine consumption may be associated with better renal function, highlighting potential dietary strategies for CKD prevention.
慢性肾脏病（CKD）是一个与心血管并发症相关的重大全球健康问题。虽然咖啡、茶和咖啡因的摄入已被证明与多种健康益处有关，但其与CKD的关系仍不明确。我们对1999 - 2018年美国国家健康与营养检查调查（NHANES）数据进行了横断面分析，纳入了49,827名参与者，通过两次24小时饮食回顾评估饮食摄入量，并使用CKD-EPI方程确定CKD状态。我们的结果显示，在调整协变量后，较高的咖啡摄入量（> 352.5克/天）与较低的CKD患病几率相关（OR = 0.760，95% CI = 0.701 - 0.823），茶的摄入量也有类似情况（OR = 0.913，95% CI = 0.843 - 0.89）。咖啡因摄入量最高三分位数组的CKD患病几率也显著降低（OR = 0.734，95% CI = 0.674 - 0.799）。这些发现表明，咖啡、茶和咖啡因的摄入可能与更好的肾功能相关，凸显了预防CKD的潜在饮食策略。
Zotero 插件