Bruce K, Becker L E
Department of Pathology (Neuropathology), Hospital for Sick Children, Canada.
Pediatr Neurosurg. 1991;17(2):74-9. doi: 10.1159/000120571.
One of the few relatively consistent pathologic observations in sudden infant death syndrome (SIDS) is astrogliosis of the brain stem. Astrogliosis is a nonspecific reactive process and its cause in SIDS, although still uncertain, is postulated to be hypoxia-ischemia. In this study, the distribution of reactive astrocytes throughout the rostral-caudal extent of the medulla has been determined. Although astrogliosis was present throughout the length of the medulla, it reached a maximum at levels 50-75% of total length, with 0% at the pontomedullary junction. Counting every reactive astrocyte through serial sections of the medulla seems unwarranted in view of the nonspecificity of the astrocytic response. This report proposes a practical approach to the quantitation of reactive astrocytes in SIDS by examining a representative sample of medulla midway through its length.
婴儿猝死综合征（SIDS）中少数相对一致的病理学观察结果之一是脑干星形胶质细胞增生。星形胶质细胞增生是一种非特异性反应过程，其在SIDS中的病因虽然仍不确定，但据推测是缺氧缺血。在本研究中，已确定反应性星形胶质细胞在延髓头端至尾端范围内的分布。虽然延髓全长均存在星形胶质细胞增生，但在全长的50%-75%水平处达到最大值，在脑桥延髓交界处为0%。鉴于星形胶质细胞反应的非特异性，对延髓连续切片中的每个反应性星形胶质细胞进行计数似乎没有必要。本报告提出了一种实用的方法，通过检查延髓长度中点的代表性样本，对SIDS中的反应性星形胶质细胞进行定量。
