Rajinikanth B Suba, Rajkumar Densingh Samuel Raj, K Keerthika, Vijayaragavan Vinothini
Pediatrics, Faculty of Medicine, Sri Lalithambigai Medical College and Hospital, Chennai, IND.
Traumatology and Orthopedics, Kursk State Medical University, Kursk, RUS.
Cureus. 2024 Feb 28;16(2):e55193. doi: 10.7759/cureus.55193. eCollection 2024 Feb.
Wound healing is an evolving and intricate technique that is vital to the restoration of tissue integrity and function. Over the past few decades, chitosan a biopolymer derived from chitin, became known as an emerging biomaterial in the field of healing wounds due to its distinctive characteristics including biocompatibility, biodegradability, affinity to biomolecules, and wound-healing activity. This natural polymer exhibits excellent healing capabilities by accelerating the development of new skin cells, reducing inflammation, and preventing infections. Due to its distinct biochemical characteristics and innate antibacterial activity, chitosan has been extensively researched as an antibacterial wound dressing. Chronic wounds, such as diabetic ulcers and liver disease, are a growing medical problem. Chitosan-based biomaterials are a promising solution in the domain of wound care. The article analyzes the depth of chitosan-based biomaterials and their impact on wound healing and also the methods to enhance the advantages of chitosan by incorporating bioactive compounds. This literature review is aimed to improve the understanding and knowledge about biomaterials and their use in wound healing.
伤口愈合是一项不断发展且复杂的技术，对于组织完整性和功能的恢复至关重要。在过去几十年中，壳聚糖这种由甲壳素衍生而来的生物聚合物，因其具有生物相容性、生物可降解性、对生物分子的亲和力以及伤口愈合活性等独特特性，成为伤口愈合领域一种新兴的生物材料。这种天然聚合物通过加速新皮肤细胞的生成、减轻炎症和预防感染，展现出卓越的愈合能力。由于其独特的生化特性和固有的抗菌活性，壳聚糖已被广泛研究用作抗菌伤口敷料。慢性伤口，如糖尿病溃疡和肝病，是一个日益严重的医学问题。基于壳聚糖的生物材料在伤口护理领域是一种很有前景的解决方案。本文分析了基于壳聚糖的生物材料的深度及其对伤口愈合的影响，以及通过加入生物活性化合物来增强壳聚糖优势的方法。这篇文献综述旨在增进对生物材料及其在伤口愈合中应用的理解和认识。
