Beems R B, van Beek L
Food Chem Toxicol. 1985 Oct;23(10):945-7. doi: 10.1016/0278-6915(85)90113-9.
The subacute toxicity of selenium was tested by feeding sodium selenite to Syrian hamsters at dietary levels of 0.1, 1, 5, 10 and 20 ppm selenium for 42 days. General health, survival and organ weights were not adversely affected at any of the dose levels. Weight gain and food intake were relatively low in males fed the highest dose level. The differences from the control values were not statistically significant and there was no similar effect in females. Hamsters fed 10 or 20 ppm retained considerably higher levels of selenium in the liver than did the controls. Microscopic examination of the liver revealed degenerative changes in males and females in the 20-ppm group. The no-toxic-effect level of selenium fed in the diet for 42 days to Syrian hamsters was found to be 10 ppm, equivalent to an intake of about 0.7 mg selenium/kg body weight/day.
通过以0.1、1、5、10和20 ppm硒的膳食水平给叙利亚仓鼠喂食亚硒酸钠42天，来测试硒的亚急性毒性。在任何剂量水平下，一般健康状况、存活率和器官重量均未受到不利影响。喂食最高剂量水平的雄性仓鼠体重增加和食物摄入量相对较低。与对照值的差异无统计学意义，雌性仓鼠未出现类似影响。喂食10或20 ppm的仓鼠肝脏中的硒水平比对照组高得多。对肝脏的显微镜检查显示，20 ppm组的雄性和雌性仓鼠都有退行性变化。发现给叙利亚仓鼠喂食42天的硒的无毒性作用水平为10 ppm，相当于约0.7毫克硒/千克体重/天的摄入量。
