Wang Chong, Zhang Zhuohao, Wang Jiali, Wang Qiao, Shang Luoran
Shanghai Xuhui Central Hospital, Zhongshan-Xuhui Hospital, And the Shanghai Key Laboratory of Medical Epigenetics, The International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology), Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China.
Mater Today Bio. 2022 Jul 8;16:100352. doi: 10.1016/j.mtbio.2022.100352. eCollection 2022 Dec.
Biohybrid materials are proceeded by integrating living cells and non-living materials to endow materials with biomimetic properties and functionalities by supporting cell proliferation and even enhancing cell functions. Due to the outstanding biocompatibility and programmability, biohybrid materials provide some promising strategies to overcome current problems in the biomedical field. Here, we review the concept and unique features of biohybrid materials by comparing them with conventional materials. We emphasize the structure design of biohybrid materials and discuss the structure-function relationships. We also enumerate the application aspects of biohybrid materials in biomedical frontiers. We believe this review will bring various opportunities to promote the communication between cell biology, material sciences, and medical engineering.
生物杂交材料是通过将活细胞与非生物材料整合而成，通过支持细胞增殖甚至增强细胞功能，赋予材料仿生特性和功能。由于其出色的生物相容性和可编程性，生物杂交材料为克服生物医学领域当前的问题提供了一些有前景的策略。在此，我们通过将生物杂交材料与传统材料进行比较，综述其概念和独特特性。我们强调生物杂交材料的结构设计，并讨论结构与功能的关系。我们还列举了生物杂交材料在生物医学前沿的应用方面。我们相信这篇综述将带来各种机会，以促进细胞生物学、材料科学和医学工程之间的交流。
