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Synaptic Protein Lactylation: A Novel Mechanism Underlying Physical Exercise-mediated Stress Resilience.

作者信息

Zhang Can-Yuan, Wei Su-Fen, Cao Xiong

机构信息

Department of Neurobiology, Key Laboratory of Mental Health of the Ministry of Education, Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, Guangdong-Hong Kong Joint Laboratory for Psychiatric Disorders, Guangdong Province Key Laboratory of Psychiatric Disorders, Guangdong Basic Research Center of Excellence for Integrated Traditional and Western Medicine for Qingzhi Diseases, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.

Department of Gastroenterology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510515, China.

出版信息

Neurosci Bull. 2025 Jul 14. doi: 10.1007/s12264-025-01467-4.

DOI:10.1007/s12264-025-01467-4
PMID:40658335
Abstract
摘要

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Synaptic Protein Lactylation: A Novel Mechanism Underlying Physical Exercise-mediated Stress Resilience.突触蛋白乳酸化：体育锻炼介导的应激恢复力的一种新机制。
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2
Physical exercise mediates cortical synaptic protein lactylation to improve stress resilience.体育锻炼介导皮质突触蛋白乳酰化以改善应激弹性。
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Acute and Chronic Resistance Training, Acute Endurance Exercise, nor Physiologically Plausible Lactate In Vitro Affect Skeletal Muscle Lactylation.急性和慢性抗阻训练、急性耐力运动，以及体外生理上合理的乳酸水平均不会影响骨骼肌的乳酸化。
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本文引用的文献

1
Physical exercise mediates cortical synaptic protein lactylation to improve stress resilience.体育锻炼介导皮质突触蛋白乳酰化以改善应激弹性。
Cell Metab. 2024 Sep 3;36(9):2104-2117.e4. doi: 10.1016/j.cmet.2024.07.018. Epub 2024 Aug 19.
2
Astrocytic lactate dehydrogenase A regulates neuronal excitability and depressive-like behaviors through lactate homeostasis in mice.星形细胞乳酸脱氢酶 A 通过调节乳酸稳态调控小鼠神经元兴奋性和抑郁样行为。
Nat Commun. 2023 Feb 9;14(1):729. doi: 10.1038/s41467-023-36209-5.
3
Exerkines in health, resilience and disease.
运动因子在健康、适应力和疾病中的作用。
Nat Rev Endocrinol. 2022 May;18(5):273-289. doi: 10.1038/s41574-022-00641-2. Epub 2022 Mar 18.
4
Positive feedback regulation of microglial glucose metabolism by histone H4 lysine 12 lactylation in Alzheimer's disease.阿尔茨海默病中组蛋白 H4 赖氨酸 12 乳酰化对小胶质细胞葡萄糖代谢的正反馈调节。
Cell Metab. 2022 Apr 5;34(4):634-648.e6. doi: 10.1016/j.cmet.2022.02.013. Epub 2022 Mar 17.
5
Protein lactylation induced by neural excitation.神经兴奋诱导蛋白质乳酰化。
Cell Rep. 2021 Oct 12;37(2):109820. doi: 10.1016/j.celrep.2021.109820.
6
Prevalence of depressive disorders and treatment in China: a cross-sectional epidemiological study.中国抑郁障碍的患病率及治疗状况：一项横断面流行病学研究。
Lancet Psychiatry. 2021 Nov;8(11):981-990. doi: 10.1016/S2215-0366(21)00251-0. Epub 2021 Sep 21.
7
Lactate is an antidepressant that mediates resilience to stress by modulating the hippocampal levels and activity of histone deacetylases.乳酰是一种抗抑郁药，通过调节组蛋白去乙酰化酶的海马水平和活性来介导对压力的适应能力。
Neuropsychopharmacology. 2019 May;44(6):1152-1162. doi: 10.1038/s41386-019-0313-z. Epub 2019 Jan 8.
8
Running Changes the Brain: the Long and the Short of It.跑步改变大脑：长短皆宜。
Physiology (Bethesda). 2017 Nov;32(6):410-424. doi: 10.1152/physiol.00017.2017.
9
Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1.运动通过乳酸受体 HCAR1 诱导脑内 VEGF 和血管生成。
Nat Commun. 2017 May 23;8:15557. doi: 10.1038/ncomms15557.
10
Differential control of learning and anxiety along the dorsoventral axis of the dentate gyrus.齿状回背腹轴上学习和焦虑的差异控制。
Neuron. 2013 Mar 6;77(5):955-68. doi: 10.1016/j.neuron.2012.12.038.