• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

姜黄素和ω-3在缓解关节疼痛和线粒体功能障碍方面可改善实验性骨关节炎的进展。

Curcumin and omega-3 ameliorate experimental osteoarthritis progression in terms of joint pain and mitochondrial dysfunction.

作者信息

Jhun JooYeon, Lee Donghwan, Na Hyun Sik, Cho Keun-Hyung, Lee Seung Yoon, Lee Jeong Su, Lee Young Joon, Kim Seok Jung, Park Sung-Hwan, Cho Mi-La

机构信息

Lab of Translational ImmunoMedicine (LaTIM), Catholic Research Institute of Medical Science, College of Medicine, The Catholic University of Korea, Seoul, 06591, Republic of Korea.

Department of Pathology, College of Medicine, The Catholic University of Korea, Seoul, 06591, Republic of Korea.

出版信息

J Inflamm (Lond). 2025 Jul 15;22(1):27. doi: 10.1186/s12950-025-00453-x.

DOI:10.1186/s12950-025-00453-x
PMID:40665304
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12265326/
Abstract

BACKGROUND

Osteoarthritis (OA), a chronic degenerative disorder, induces pain, joint inflammation, and destruction of the articular cartilage matrix. Curcumin and omega-3 have been used as dietary supplements for OA due to their anti-inflammatory and antioxidant properties. However, there is no evidence demonstrating a synergistic effect in OA. The current study aimed to investigate the therapeutic effects and underlying mechanism of a combination of curcumin and omega-3 in the treatment of OA.

METHODS

Wistar rats were injected with monosodium iodoacetate to induce OA. Oral treatments of a vehicle, curcumin, curcumin and omega 3, or celecoxib were administered. Pain was analyzed according to the paw withdrawal latency, paw withdrawal threshold, and weight bearing ability. The joint was isolated from OA rats, and cartilage damage was evaluated using histomorphological techniques, the Mankin scoring system, and micro computed tomography analysis. Protein expression in the joint was examined using immunohistochemistry. The expression levels of catabolic markers were measured in curcumin and omega-3-treated OA chondrocytes.

RESULTS

The OA animal model revealed diminished pain and cartilage conservation in response to the combined treatment. mRNA levels of matrix metalloproteinase 1 (MMP1), MMP3, and MMP13 were reduced in interleukin-1 beta-simulated human OA chondrocytes. Additionally, mitochondrial markers, cytochrome c oxidase 4, and TOMM20, were increased by the combination treatment.

CONCLUSIONS

These findings suggest promising therapeutic outcomes for the combined treatment of curcumin and omega-3 in OA patients.

摘要

背景

骨关节炎（OA）是一种慢性退行性疾病，会引发疼痛、关节炎症以及关节软骨基质的破坏。姜黄素和ω-3因其抗炎和抗氧化特性，已被用作OA的膳食补充剂。然而，尚无证据表明它们在OA中具有协同作用。本研究旨在探究姜黄素和ω-3联合治疗OA的疗效及潜在机制。

方法

向Wistar大鼠注射碘乙酸钠以诱导OA。分别给予溶剂、姜黄素、姜黄素与ω-3联合用药或塞来昔布进行口服治疗。根据爪部缩腿潜伏期、爪部缩腿阈值和负重能力分析疼痛情况。从OA大鼠分离关节，使用组织形态学技术、曼金评分系统和微型计算机断层扫描分析评估软骨损伤。采用免疫组织化学法检测关节中的蛋白表达。测定姜黄素和ω-3处理的OA软骨细胞中分解代谢标志物的表达水平。

结果

OA动物模型显示联合治疗可减轻疼痛并保护软骨。在白细胞介素-1β模拟的人OA软骨细胞中，基质金属蛋白酶1（MMP1）、MMP3和MMP13的mRNA水平降低。此外，联合治疗可增加线粒体标志物细胞色素c氧化酶4和TOMM20。

结论

这些发现表明姜黄素和ω-3联合治疗OA患者有望取得良好的治疗效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae42/12265326/5f30848d0250/12950_2025_453_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae42/12265326/33a8e2db8753/12950_2025_453_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae42/12265326/f5ee3c26066b/12950_2025_453_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae42/12265326/8e3cad33cc60/12950_2025_453_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae42/12265326/7823beb5ee66/12950_2025_453_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae42/12265326/46a5e290ff76/12950_2025_453_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae42/12265326/5f30848d0250/12950_2025_453_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae42/12265326/33a8e2db8753/12950_2025_453_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae42/12265326/f5ee3c26066b/12950_2025_453_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae42/12265326/8e3cad33cc60/12950_2025_453_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae42/12265326/7823beb5ee66/12950_2025_453_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae42/12265326/46a5e290ff76/12950_2025_453_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae42/12265326/5f30848d0250/12950_2025_453_Fig6_HTML.jpg

相似文献

1
Curcumin and omega-3 ameliorate experimental osteoarthritis progression in terms of joint pain and mitochondrial dysfunction.姜黄素和ω-3在缓解关节疼痛和线粒体功能障碍方面可改善实验性骨关节炎的进展。
J Inflamm (Lond). 2025 Jul 15;22(1):27. doi: 10.1186/s12950-025-00453-x.
2
Phenotypic screening identified polydatin alleviating cartilage degeneration by modulating SIRT3-dependent mitochondrial dysfunction.表型筛选确定白藜芦醇苷通过调节SIRT3依赖性线粒体功能障碍来减轻软骨退变。
Phytomedicine. 2025 Aug;144:156948. doi: 10.1016/j.phymed.2025.156948. Epub 2025 Jun 3.
3
Celecoxib for osteoarthritis.塞来昔布用于骨关节炎
Cochrane Database Syst Rev. 2017 May 22;5(5):CD009865. doi: 10.1002/14651858.CD009865.pub2.
4
Hyaluronic acid and other conservative treatment options for osteoarthritis of the ankle.透明质酸及踝关节骨关节炎的其他保守治疗选择
Cochrane Database Syst Rev. 2015 Oct 17;2015(10):CD010643. doi: 10.1002/14651858.CD010643.pub2.
5
WITHDRAWN: Non-aspirin, non-steroidal anti-inflammatory drugs for treating osteoarthritis of the knee.撤回：用于治疗膝关节骨关节炎的非阿司匹林非甾体抗炎药。
Cochrane Database Syst Rev. 2007 Jul 18;2006(1):CD000142. doi: 10.1002/14651858.CD000142.pub2.
6
Human Infrapatellar Fat Pad Mesenchymal Stem Cell-derived Extracellular Vesicles Purified by Anion Exchange Chromatography Suppress Osteoarthritis Progression in a Mouse Model.阴离子交换层析法纯化的人髌下脂肪垫间充质干细胞来源细胞外囊泡抑制骨关节炎在小鼠模型中的进展。
Clin Orthop Relat Res. 2024 Jul 1;482(7):1246-1262. doi: 10.1097/CORR.0000000000003067. Epub 2024 Apr 19.
7
Non-surgical interventions for treating osteoarthritis of the big toe joint.非手术干预治疗大脚趾关节骨关节炎。
Cochrane Database Syst Rev. 2024 Jun 17;6(6):CD007809. doi: 10.1002/14651858.CD007809.pub3.
8
Vitamin D Alleviates Osteoarthritis Progression by Targeting Cartilage and Subchondral Bone via Myd88-TAK1-ERK Axis Suppression.维生素D通过抑制Myd88-TAK1-ERK轴靶向软骨和软骨下骨减轻骨关节炎进展。
Drug Des Devel Ther. 2025 Jul 8;19:5855-5870. doi: 10.2147/DDDT.S526064. eCollection 2025.
9
Acupuncture for hip osteoarthritis.针灸治疗髋骨关节炎
Cochrane Database Syst Rev. 2018 May 5;5(5):CD013010. doi: 10.1002/14651858.CD013010.
10
Effects of curcumin on serum inflammatory biomarkers in patients with knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials.姜黄素对膝骨关节炎患者血清炎症生物标志物的影响：一项随机对照试验的系统评价和荟萃分析
BMC Complement Med Ther. 2025 Jul 4;25(1):237. doi: 10.1186/s12906-025-04951-6.

本文引用的文献

1
The efficacy and safety of Curcuma longa extract and curcumin supplements on osteoarthritis: a systematic review and meta-analysis.姜黄提取物和姜黄素补充剂治疗骨关节炎的疗效和安全性：系统评价和荟萃分析。
Biosci Rep. 2021 Jun 25;41(6). doi: 10.1042/BSR20210817.
2
Relationship of Bone Mineral Density and Knee Osteoarthritis (Kellgren-Lawrence Grade): Fifth Korea National Health and Nutrition Examination Survey.骨密度与膝关节骨关节炎（Kellgren-Lawrence 分级）的关系：第五次韩国国家健康和营养检查调查。
Clin Orthop Surg. 2021 Mar;13(1):60-66. doi: 10.4055/cios20111. Epub 2021 Feb 15.
3
Autologous cell-free serum preparations in the management of knee osteoarthritis: what is the current clinical evidence?
自体无细胞血清制剂在膝关节骨关节炎治疗中的应用：当前临床证据如何？
Knee Surg Relat Res. 2020 Mar 23;32(1):16. doi: 10.1186/s43019-020-00036-5.
4
The metaphyseal sleeve: an unexplored option in the treatment of complex primary knee osteoarthritis.干骺端套管：治疗复杂原发性膝关节骨关节炎的一种未被探索的选择。
Knee Surg Relat Res. 2020 Apr 16;32(1):20. doi: 10.1186/s43019-020-00032-9.
5
Clinical and Radiological Changes after Microfracture of Knee Chondral Lesions in Middle-Aged Asian Patients.中年亚洲患者膝关节软骨病变行微骨折术后的临床和影像学变化。
Clin Orthop Surg. 2019 Sep;11(3):282-290. doi: 10.4055/cios.2019.11.3.282. Epub 2019 Aug 12.
6
Effect of chondrocyte mitochondrial dysfunction on cartilage degeneration: A possible pathway for osteoarthritis pathology at the subcellular level.软骨细胞线粒体功能障碍对软骨退变的影响：亚细胞水平骨关节炎病理的可能途径。
Mol Med Rep. 2019 Oct;20(4):3308-3316. doi: 10.3892/mmr.2019.10559. Epub 2019 Aug 6.
7
Role of mitochondrial dysfunction on rheumatic diseases.线粒体功能障碍在风湿性疾病中的作用。
Biochem Pharmacol. 2019 Jul;165:181-195. doi: 10.1016/j.bcp.2019.03.008. Epub 2019 Mar 9.
8
Emicizumab, a humanized bispecific antibody to coagulation factors IXa and X with a factor VIIIa-cofactor activity.依库珠单抗，一种人源化的双特异性抗体，靶向凝血因子 IXa 和 X，同时具有因子 VIIIa 辅因子活性。
Int J Hematol. 2020 Jan;111(1):20-30. doi: 10.1007/s12185-018-2545-9. Epub 2018 Oct 22.
9
Fatty acids and osteoarthritis: different types, different effects.脂肪酸与骨关节炎：不同类型，不同作用。
Joint Bone Spine. 2019 Jul;86(4):451-458. doi: 10.1016/j.jbspin.2018.07.005. Epub 2018 Aug 3.
10
Targeting aging for disease modification in osteoarthritis.针对骨关节炎疾病修饰的衰老靶向治疗。
Curr Opin Rheumatol. 2018 Jan;30(1):101-107. doi: 10.1097/BOR.0000000000000456.