Weinstein G D, McCullough J L, Ross P A
J Invest Dermatol. 1985 Dec;85(6):579-83. doi: 10.1111/1523-1747.ep12283594.
Studies on the cell proliferation kinetics of psoriatic epidermal cells are presented and the results compared to similar studies for normal epidermis. The short 36-h duration of the psoriatic cell cycle (Tc) is confirmed with the first double-peaked fraction of labeled mitoses (FLM) curve in human subjects. The growth fraction of psoriasis using two experimental techniques approximates 100% within 36 h, confirming the rapid Tc found by the FLM method. The cell kinetic basis for the pathophysiology of psoriasis consists of at least 3 proliferative abnormalities in comparison to normal epidermis. By far the largest alteration is the shortening of the Tc from 311 to 36 h. There is also a doubling of the proliferative cell population in psoriasis from 27,000 to 52,000 cells/mm and an increase in the growth fraction from 60% to 100%. As a consequence of these abnormalities the psoriatic epidermis produces 35,000 cells/day from a proliferative compartment of 52,000 cells/mm2 surface area. This is a 28-fold greater production of cells than the 1,246 cells/day produced in normal epidermis. The biochemical or control factors leading to these kinetic differences continue to remain elusive.
本文介绍了银屑病表皮细胞的细胞增殖动力学研究，并将结果与正常表皮的类似研究进行了比较。在人类受试者中，通过标记有丝分裂的第一个双峰部分（FLM）曲线，证实了银屑病细胞周期（Tc）较短，为36小时。使用两种实验技术，银屑病的生长分数在36小时内接近100%，证实了通过FLM方法发现的快速Tc。与正常表皮相比，银屑病病理生理学的细胞动力学基础至少包括3种增殖异常。到目前为止，最大的变化是Tc从311小时缩短到36小时。银屑病中增殖细胞群体也增加了一倍，从27,000个细胞/mm增加到52,000个细胞/mm，生长分数从60%增加到100%。由于这些异常，银屑病表皮从每平方毫米表面积52,000个细胞的增殖区每天产生35,000个细胞。这是正常表皮每天产生1,246个细胞的28倍。导致这些动力学差异的生化或控制因素仍然难以捉摸。
