Besch N F, Smith C G, Besch P K, Kaufman R H
Am J Obstet Gynecol. 1977 Jul 15;128(6):635-42. doi: 10.1016/0002-9378(77)90209-5.
Despite the widespread use of marihuana by large numbers of young adults in the reproductive years, little is known about the effects of this drug on reproductive function. information on the effect of the drug on the woman is particularly meager. The rhesus monkey provides an excellent animal model from which to generalize to man. While the primary purpose of the project is to determine the effect of long-term administration on the cycling female monkey, the initial studies were carried out in the ovariectomized monkey with resulting elevated gonadotropin levels under conditions of short-term administration of the drug. Marihuana causes a reversible depression in luteinizing hormone levels in the ovariectomized female rhesus monkey.
尽管大量处于生育年龄的年轻人广泛使用大麻，但对于这种药物对生殖功能的影响却知之甚少。关于该药物对女性影响的信息尤其匮乏。恒河猴提供了一个很好的可推广至人类的动物模型。虽然该项目的主要目的是确定长期给药对处于发情周期的雌性猴子的影响，但最初的研究是在卵巢切除的猴子身上进行的，在短期给药的情况下，这些猴子的促性腺激素水平升高。大麻会导致卵巢切除的雌性恒河猴促黄体生成素水平出现可逆性下降。
