Xu Tingting, Kong Jie, Chen Yu, Cui Wenxue, Fang Yucheng, Zhang Wei, Wang Mohan, Zhou Meng, Li Yingwei, Jin Rongchao, Song Yongbo
School of Biomedical Engineering, Research and Engineering Center of Biomedical Materials, Anhui Medical University, Hefei, Anhui, 230032, P. R. China.
Hefei National Research Center for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, Anhui, 230026, P. R. China.
Adv Sci (Weinh). 2025 Oct;12(39):e09283. doi: 10.1002/advs.202509283. Epub 2025 Jul 18.
Atomically precise gold nanoclusters (NCs) hold great potential in optical and bio-related applications due to their well-defined atomic structures, near-infrared-II (NIR-II) photoluminescence, and excellent biocompatibility. However, many applications require multi-functionality in one entity, which poses significant challenges in the design of materials. Herein, a novel CuAu NC is designed, exhibiting triple functionality, including NIR-II luminescence, strong photothermal effect, and high catalytic activity. Crystallographic analysis reveals a penta-icosahedral, oblate structure, with the Cu atoms being exclusively located in the core region, including one additional Cu atom at the center of the CuAu structure. By comparing with the related, undoped Au NC -which is non-emissive and photocatalytically inactive, deep insights into the enhancement mechanisms are obtained. Furthermore, a multifunctional CuAu@SiO-FA (folic acid) nanoplatform is constructed for potential bio-applications.
原子精确的金纳米团簇（NCs）由于其明确的原子结构、近红外二区（NIR-II）光致发光和优异的生物相容性，在光学和生物相关应用中具有巨大潜力。然而，许多应用需要一个实体具备多功能性，这对材料设计提出了重大挑战。在此，设计了一种新型的CuAu NC，它具有三重功能，包括NIR-II发光、强光热效应和高催化活性。晶体学分析揭示了一种五重二十面体扁球形结构，其中Cu原子仅位于核心区域，包括在CuAu结构中心的一个额外Cu原子。通过与相关的未掺杂Au NC（其不发光且无光催化活性）进行比较，深入了解了增强机制。此外，构建了一种多功能CuAu@SiO-FA（叶酸）纳米平台用于潜在的生物应用。
