基于分子印迹聚合物功能化的温度补偿反射结构的用于孕酮浓度检测的先进光纤传感器。

Advanced optic-fiber sensor for progesterone concentration detection relying on the temperature-compensated reflective structure functionalized with molecularly imprinted polymer.

作者信息

Liu Hanlin, Liu Miao, Guo Shuyuan, Mao Jingru, Zou Yongfeng, Yu Yuejiang, Sun Dandan, Ma Jie

机构信息

School of Physics and Electronic Engineering, Shanxi University, Taiyuan 030006, China.

Shanxi Key Laboratory of Wireless Communication and Detection, Shanxi University, Taiyuan 030006, China.

出版信息

Food Chem X. 2025 Jul 7;29:102742. doi: 10.1016/j.fochx.2025.102742. eCollection 2025 Jul.

A cascaded optic-reflector sensing system combining a microfiber interferometer (MFI) and a gold-coated tilted fiber Bragg grating (TFBG) is proposed for detecting progesterone (PG) concentration. The sensor uses molecularly imprinted polymers (MIP) as a recognition layer and metal-organic frameworks (MOFs) for enhanced sensitivity. The remove and rebind of PG will both cause changes in the local refractive index (RI) on MFI, and these changes can be monitored by the intensity variations on TFBG. Experimental results show a detection range of 10-20 μg/ml, with a sensitivity of 41,837 dB/(μg/ml) and a limit of detection (LOD) of 10 μg/ml. Simultaneously, it has been established that the sensor has good specificity in ten different real samples. This cascaded structure reflective sensor provides a simple and reliable technology for the quantitative detection of PG concentration in dairy products and water.

提出了一种结合微光纤干涉仪（MFI）和镀金倾斜光纤布拉格光栅（TFBG）的级联光学反射器传感系统，用于检测孕酮（PG）浓度。该传感器使用分子印迹聚合物（MIP）作为识别层，并采用金属有机框架（MOF）来提高灵敏度。PG的去除和重新结合都会导致MFI上局部折射率（RI）的变化，这些变化可以通过TFBG上的强度变化来监测。实验结果表明，检测范围为10 - 20μg/ml，灵敏度为41,837dB/(μg/ml)，检测限（LOD）为10μg/ml。同时，已确定该传感器在十种不同的实际样品中具有良好的特异性。这种级联结构反射传感器为乳制品和水中PG浓度的定量检测提供了一种简单可靠的技术。