Prokopowicz J, Kemona H, Wysocka J, Kiluk S
Neoplasma. 1985;32(5):605-11.
Lysozyme activity was determined in undiluted and diluted sera of 30 patients with lung carcinoma and of 40 healthy individuals. Blood was collected before radiotherapy, in half of its course, just after completion of radiotherapy, and three weeks and three months later. In the controls the same time spacing was kept. Lysozyme was found to be increased both in undiluted and diluted sera. Enhancement of the lysozyme activity may be due to the presence of immune complexes (antigen--antibody) which are probably responsible for the release of the enzyme from the viable neutrophils. High activity in diluted sera indicates an increase of lysozyme inhibitors in sera of cancer patients. Radiotherapy has not induced significant changes in the enzyme, either during its course of after its completion as confirmed by three-month observation. Taking into consideration the role of the lysozyme in anticancer mechanisms it appears that determination of its activity may be of value in the course of cancer disease.
测定了30例肺癌患者和40名健康个体未稀释及稀释血清中的溶菌酶活性。在放疗前、放疗进行到一半时、放疗刚结束时以及放疗后三周和三个月采集血液。对照组保持相同的时间间隔。发现未稀释和稀释血清中的溶菌酶均升高。溶菌酶活性增强可能是由于免疫复合物（抗原 - 抗体）的存在，这些复合物可能负责从存活的中性粒细胞中释放该酶。稀释血清中的高活性表明癌症患者血清中溶菌酶抑制剂增加。三个月的观察证实，放疗期间及放疗结束后该酶均未发生显著变化。考虑到溶菌酶在抗癌机制中的作用，其活性测定在癌症病程中似乎具有一定价值。
