Nash Deborah M, Giles Joanna L
Department of Life Sciences, Aberystwyth University, Penglais, Aberystwyth, UK.
Nat Rev Immunol. 2025 Jul 22. doi: 10.1038/s41577-025-01200-2.
Uterine inflammation encompasses several conditions, including endometritis, which is a local innate immune response, usually to bacteria. Endometritis is an important veterinary and medical problem that can result in infertility and/or recurrent pregnancy loss. This Review aims to summarize animal models that can be used to uncover the immune pathways responsible for uterine inflammation and their value for screening novel, putative therapies. We discuss large animal models of endometritis, particularly the well-used bovine system and the value that may be added by further developing porcine systems. Animal cells and tissue explants can be ethically sourced, and these models can replace or reduce the need for live animal studies and overcome the practical issues of harvesting endometrial material from women. We explain how these models of endometritis show great potential for advancing our understanding of the immune dysfunction underlying susceptibility to the condition, and for early-stage drug discovery.
子宫炎症包括多种病症，其中包括子宫内膜炎，它是一种通常针对细菌的局部先天性免疫反应。子宫内膜炎是一个重要的兽医和医学问题，可导致不孕和/或反复流产。本综述旨在总结可用于揭示导致子宫炎症的免疫途径的动物模型及其在筛选新型潜在疗法方面的价值。我们讨论了子宫内膜炎的大型动物模型，特别是常用的牛模型以及进一步开发猪模型可能带来的价值。动物细胞和组织外植体可以通过符合伦理的方式获取，这些模型可以替代或减少活体动物研究的需求，并克服从女性身上获取子宫内膜材料的实际问题。我们解释了这些子宫内膜炎模型如何在推进我们对该病症易感性背后的免疫功能障碍的理解以及早期药物发现方面显示出巨大潜力。
