Doueihy Nour El, Ghaleb Joya, Kfoury Karl, Khouzami Katy Kaleen, Nassif Nicolas, Attieh Philippe, Ghadieh Hilda E, Azar Sami, Kanaan Amjad, Harb Frederic
Faculty of Medicine and Medical Sciences, University of Balamand, Tripoli P.O. Box 100, Lebanon.
J Xenobiot. 2025 Jul 7;15(4):114. doi: 10.3390/jox15040114.
Aspartame, a widely used artificial sweetener, has been at the center of ongoing debates concerning its safety, particularly its potential role in cancer development. This review provides an overview and analysis of the current research exploring the carcinogenic effects of aspartame. It examines findings from in vitro studies, in vivo experiments, and epidemiological investigations to offer a comprehensive perspective on the controversy. The results from these studies remain inconsistent-some suggest a possible association between high aspartame intake and increased cancer risk, while others fail to establish a conclusive link. Additionally, this review explores potential mechanisms by which aspartame could exert carcinogenic effects, focusing on its metabolic byproducts and their influence on cellular and molecular processes. Despite these investigations, the question of aspartame's safety remains unresolved. Continued research is essential to clarify its role in cancer risk and to inform evidence-based dietary guidelines.
阿斯巴甜是一种广泛使用的人工甜味剂，一直是关于其安全性，尤其是其在癌症发展中潜在作用的持续辩论的焦点。本综述对目前探索阿斯巴甜致癌作用的研究进行了概述和分析。它审视了体外研究、体内实验和流行病学调查的结果，以提供关于这一争议的全面观点。这些研究的结果仍然不一致——一些研究表明高阿斯巴甜摄入量与癌症风险增加之间可能存在关联，而另一些研究则未能确立确凿的联系。此外，本综述探讨了阿斯巴甜可能发挥致癌作用的潜在机制，重点关注其代谢副产物及其对细胞和分子过程的影响。尽管进行了这些调查，阿斯巴甜的安全性问题仍未得到解决。持续的研究对于阐明其在癌症风险中的作用并为基于证据的饮食指南提供依据至关重要。
