Törteli Levente, Simon Péter, Berkecz Róbert, Szatmári István
Institute of Pharmaceutical Chemistry, University of Szeged Eötvös u. 6 H-6720 Szeged Hungary
Institute of Pharmaceutical Analysis, Faculty of Pharmacy, University of Szeged Somogyi utca 4 H-6720 Szeged Hungary.
RSC Adv. 2025 Jul 23;15(32):26420-26427. doi: 10.1039/d5ra04301h. eCollection 2025 Jul 21.
The latest findings in the literature show that kynurenic acid and its analogues are potent drug candidates against numerous neurological diseases. In this article, kynurenic acid derivatives were treated with NaOCl and NaOBr solutions and yielded the corresponding 3-halogeno compounds. The reaction is fast and conducted under mild conditions, and the yields are efficient just like the previous methods available for the same transformation. These newly synthesized halogeno compounds can serve as starting materials for the synthesis of 3-aminokynurenic acid analogues by treating the 3-bromokynurenic acid analogue with NaN. The solvent effect of this reaction was also examined. These reactions are suitable for the synthesis of 3-heterosubstituted kynurenic acid analogues.
文献中的最新研究结果表明，犬尿喹啉酸及其类似物是针对多种神经疾病的有效候选药物。在本文中，犬尿喹啉酸衍生物用次氯酸钠和次溴酸钠溶液处理，得到相应的3-卤代化合物。该反应速度快，在温和条件下进行，产率与之前用于相同转化的方法一样高效。这些新合成的卤代化合物可作为通过用NaN处理3-溴犬尿喹啉酸类似物来合成3-氨基犬尿喹啉酸类似物的起始原料。还研究了该反应的溶剂效应。这些反应适用于合成3-杂取代犬尿喹啉酸类似物。
