Tassine Hanae, Allaoui Abire, Naitlhou Abdelhamid
Department of Internal Medicine, Mohammed VI International University Hospital, Mohammed VI University of Health Sciences (UM6SS), Casablanca, MAR.
Department of Internal Medicine, Cheikh Khalifa University Hospital, Mohammed VI University of Health Sciences (UM6SS), Casablanca, MAR.
Cureus. 2025 Jun 23;17(6):e86574. doi: 10.7759/cureus.86574. eCollection 2025 Jun.
Rowell syndrome is a rare clinical entity, defined by the association of systemic lupus erythematosus (SLE) and erythema multiforme (EM)-like skin lesions, accompanied by distinctive immunological findings such as a speckled antinuclear antibody (ANA) pattern. It predominantly affects women and requires specific diagnostic criteria. Management depends on the extent and severity of organ involvement. We report the case of a 69-year-old woman who developed severe mucocutaneous erythema multiforme-like lesions and systemic symptoms. Clinical and laboratory findings supported the diagnosis of SLE. Targeted treatment combining corticosteroids and hydroxychloroquine resulted in marked clinical and biological improvement.
罗威尔综合征是一种罕见的临床病症，定义为系统性红斑狼疮（SLE）与多形红斑（EM）样皮肤损害相关联，并伴有如斑点状抗核抗体（ANA）模式等独特的免疫学表现。它主要影响女性，需要特定的诊断标准。治疗取决于器官受累的程度和严重性。我们报告了一例69岁女性患者，她出现了严重的黏膜皮肤多形红斑样损害及全身症状。临床和实验室检查结果支持SLE的诊断。联合使用皮质类固醇和羟氯喹的靶向治疗使临床和生物学指标有了显著改善。
