Ahmadi Nayebali, Shahali Maryam, Alamdary Ashkan, Gholami Alireaza, Moukhah Rasul, Tehrani Mohammadjavad Hossein, Doroud Delaram, Alavi Ariana, Mardani Rajab
Proteomics Research Center, Department of Medical Lab Sciences, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Viral Vaccines, Production and Complex Research, Pasteur Institute of Iran, Tehran, Iran.
Tanaffos. 2024 Mar;23(3):238-245.
The new coronavirus infectious disease, COVID-19, is constantly killing people around the world. The main clinical symptoms of COVID-19 include fever, cough, shortness of breath, weakness, fatigue, and sputum/discharge. Gastrointestinal (GI) impairments are often associated with respiratory manifestations in COVID-19 patients. The current study aimed to examine potential laboratory markers in COVID-19 patients with gastrointestinal impairments as prognosticators of disease severity.
In the present study, hospitalized COVID-19 patients with respiratory symptoms as the main clinical manifestations and gastrointestinal symptoms were studied to evaluate relevant blood biomarkers including vitamins B12, D, and K in addition to albumin, pre-albumin, calcium, and magnesium.
Sixty individuals (29 males and 31 females) participated in the study aged between 29 and 72 years, with a mean of 45.87 years. Our results showed a significant increase in albumin, pre-albumin, transferrin, and vitamin K and a significant decrease in magnesium and vitamin B12. Decreases in calcium and vitamin D were modestly associated with the clinical picture of the patient group.
Our findings suggest that monitoring laboratory markers such as transferrin, serum albumin, vitamin K, and magnesium-to-calcium ratio could be valuable prognosticators for COVID-19 infection. They could assist in better patient management and disease control.
新型冠状病毒感染疾病，即COVID-19，正在全球持续夺命。COVID-19的主要临床症状包括发热、咳嗽、呼吸急促、虚弱、乏力以及咳痰/排出物。胃肠道（GI）损伤常与COVID-19患者的呼吸道表现相关。本研究旨在检测伴有胃肠道损伤的COVID-19患者体内的潜在实验室标志物，以作为疾病严重程度的预后指标。
在本研究中，对以呼吸道症状为主要临床表现且伴有胃肠道症状的住院COVID-19患者进行研究，以评估相关血液生物标志物，包括维生素B12、D和K，以及白蛋白、前白蛋白、钙和镁。
60名个体（29名男性和31名女性）参与了本研究，年龄在29至72岁之间，平均年龄为45.87岁。我们的结果显示，白蛋白、前白蛋白、转铁蛋白和维生素K显著升高，而镁和维生素B12显著降低。钙和维生素D的降低与患者组的临床表现有一定关联。
我们的研究结果表明，监测转铁蛋白、血清白蛋白、维生素K以及镁钙比等实验室标志物可能有助于预测COVID-19感染的预后。它们有助于更好地管理患者和控制疾病。
