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司库奇尤单抗成功治疗难治性滑膜炎、痤疮、脓疱病、骨肥厚和骨炎（SAPHO）综合征及反常性银屑病：一例报告

Successful Treatment of Refractory Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis (SAPHO) Syndrome and Paradoxical Psoriasis with Secukinumab: A Case Report.

作者信息

Fan Danyang, Li Fuqiu, Liu Zhe, Tang Zhanhan, Lv Sha

机构信息

Department of Dermatology, The Second Hospital of Jilin University, Changchun, Jilin, 130000, People's Republic of China.

出版信息

Clin Cosmet Investig Dermatol. 2024 Mar 5;17:547-552. doi: 10.2147/CCID.S454057. eCollection 2024.

DOI:10.2147/CCID.S454057
PMID:38476341
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10929232/
Abstract

Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a rare chronic inflammatory disease mainly manifested as skin and osteoarticular lesions. Herein, we describe a female patient with SAPHO syndrome exhibited paradoxical psoriasis and primary palmoplantar pustulosis (PPP) worsened during treatment with adalimumab. We then switched to secukinumab and obtained significant improvement in both skin lesions and osteoarticular pain. These findings suggest that secukinumab might be an appropriate option for patients with SAPHO syndrome who present with TNF-α-inhibitor-induced paradoxical psoriasis.

摘要

滑膜炎、痤疮、脓疱病、骨质增生和骨炎（SAPHO）综合征是一种罕见的慢性炎症性疾病，主要表现为皮肤和骨关节病变。在此，我们描述了一名患有SAPHO综合征的女性患者，其在使用阿达木单抗治疗期间出现矛盾性银屑病和原发性掌跖脓疱病（PPP）加重的情况。然后我们改用司库奇尤单抗，皮肤病变和骨关节疼痛均得到显著改善。这些发现表明，对于出现TNF-α抑制剂诱导的矛盾性银屑病的SAPHO综合征患者，司库奇尤单抗可能是一种合适的选择。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a34a/10929232/fe08d0004a71/CCID-17-547-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a34a/10929232/a414dfbbe1d0/CCID-17-547-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a34a/10929232/fe08d0004a71/CCID-17-547-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a34a/10929232/a414dfbbe1d0/CCID-17-547-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a34a/10929232/fe08d0004a71/CCID-17-547-g0002.jpg

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本文引用的文献

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SAPHO syndrome: current clinical, diagnostic and treatment approaches.SAPHO 综合征：当前的临床、诊断和治疗方法。
Rheumatol Int. 2024 Nov;44(11):2301-2313. doi: 10.1007/s00296-023-05491-3. Epub 2023 Oct 27.
2
Paradoxical Tumor Necrosis Factor-Alpha (TNF-α) Inhibitor-Induced Psoriasis: A Systematic Review of Pathogenesis, Clinical Presentation, and Treatment.矛盾性肿瘤坏死因子-α（TNF-α）抑制剂诱导的银屑病：发病机制、临床表现及治疗的系统评价
Cureus. 2023 Aug 1;15(8):e42791. doi: 10.7759/cureus.42791. eCollection 2023 Aug.
3
Successful Treatment of SAPHO Syndrome Complicated with Ankylosing Spondylitis by Secukinumab: A Case Report.
The Role of IL-17 in Systemic Autoinflammatory Diseases: Mechanisms and Therapeutic Perspectives.
白细胞介素-17在全身自身炎症性疾病中的作用：机制与治疗前景
Clin Rev Allergy Immunol. 2025 Mar 12;68(1):27. doi: 10.1007/s12016-025-09042-5.
4
What Is New and What Is Next for SAPHO Syndrome Management: A Narrative Review.SAPHO综合征管理的新进展与未来方向：一篇叙述性综述
J Clin Med. 2025 Feb 18;14(4):1366. doi: 10.3390/jcm14041366.
司库奇尤单抗成功治疗合并强直性脊柱炎的SAPHO综合征：一例报告
J Pers Med. 2023 Mar 13;13(3):516. doi: 10.3390/jpm13030516.
4
Exceptional response of skin symptoms to secukinumab treatment in a patient with SAPHO syndrome: Case report and literature review.SAPHO 综合征患者皮肤症状对司库奇尤单抗治疗的显著反应：病例报告及文献复习。
Medicine (Baltimore). 2022 Aug 19;101(33):e30065. doi: 10.1097/MD.0000000000030065.
5
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7
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Dermatology. 2022;238(5):860-869. doi: 10.1159/000521263. Epub 2022 Jan 14.
8
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J Dermatol. 2021 Jun;48(6):750-760. doi: 10.1111/1346-8138.15826. Epub 2021 Mar 2.
9
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Rheumatology (Oxford). 2021 Jan 5;60(1):473-474. doi: 10.1093/rheumatology/keaa352.
10
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Ther Adv Musculoskelet Dis. 2020 May 12;12:1759720X20912865. doi: 10.1177/1759720X20912865. eCollection 2020.