L'Oréal Research and Innovation, L'Oréal, 1 avenue Eugène Schueller, 93360, Aulnay-sous-Bois, France.
Int J Cosmet Sci. 2019 Jun;41(3):213-220. doi: 10.1111/ics.12523. Epub 2019 May 6.
Recent findings showed that skin ageing preferentially affects human papillary dermal fibroblasts suggesting that the papillary dermis represents a critical zone altered by skin ageing. Based on these findings, we investigated the potential anti-ageing effect of rhamnose.
We investigated the potential anti-ageing effect of rhamnose using in vitro reconstructed skin containing fibroblasts obtained either from young or old donors, and in vivo clinical investigation.
We detected positive effects of rhamnose in both epidermal and dermal compartments of in vitro reconstructed skin. Moreover, we were able to show that such in vitro findings were also obtained in vivo including an effect on collagen IV and procollagen I production.
We provide evidence that rhamnose has a potentially beneficial effect on papillary dermis and dermal-epidermal junction, both of the areas which are affected by skin ageing.
最近的研究结果表明，皮肤老化优先影响人乳头真皮成纤维细胞，这表明乳头真皮是受皮肤老化影响的关键区域。基于这些发现，我们研究了鼠李糖的潜在抗衰老作用。
我们使用含有年轻或老年供体来源的成纤维细胞的体外重建皮肤，以及体内临床研究，研究了鼠李糖的潜在抗衰老作用。
我们在体外重建皮肤的表皮和真皮部分均检测到了鼠李糖的积极作用。此外，我们能够证明这种体外发现也存在于体内，包括对胶原蛋白 IV 和前胶原蛋白 I 产生的影响。
我们提供的证据表明，鼠李糖对受皮肤老化影响的乳头真皮和真皮-表皮交界处具有潜在的有益作用。
