Le Phan Gia, Kim Daesoo, Chung Jae-Pil, Cho Sungbo
Department of Electronic Engineering, Gachon University, Seongnam-si 13120, Republic of Korea.
Department of Semiconductor Engineering, Gachon University, Seongnam-si 13120, Republic of Korea.
Biosensors (Basel). 2025 Jul 7;15(7):435. doi: 10.3390/bios15070435.
Nanozymes constitute a rapidly advancing frontier in scientific research, attracting widespread international interest, particularly for their role in facilitating cascade reactions. Despite their initial discovery a few years ago, significant hurdles persist in optimizing their catalytic performance and substrate specificity-challenges that are especially critical in the context of biomedical diagnostics. Within this domain, nitrogen-containing graphene oxide-based nanozymes exhibiting peroxidase-mimicking activity have emerged as particularly promising candidates, owing to the exceptional electrical conductivity, mechanical flexibility, and structural resilience of reduced graphene oxide-based materials. Intensive efforts have been devoted to engineering graphene oxide structures to enhance their peroxidase-like functionality. Nonetheless, the practical implementation of such nanozymes remains under active investigation and demands further refinement. This review synthesizes the current developments in nitrogen heteroatom-containing graphene oxide nanozymes and their derivative nanozymes, emphasizing recent breakthroughs and biomedical applications. It concludes by exploring prospective directions and the broader potential of these materials in the biomedical landscape.
纳米酶是科学研究中一个迅速发展的前沿领域，引起了国际社会的广泛关注，特别是因其在促进级联反应中的作用。尽管它们在几年前才首次被发现，但在优化其催化性能和底物特异性方面仍存在重大障碍，这些挑战在生物医学诊断领域尤为关键。在这一领域，具有过氧化物酶模拟活性的含氮氧化石墨烯基纳米酶因其基于还原氧化石墨烯材料的卓越导电性、机械柔韧性和结构弹性而成为特别有前景的候选物。人们已投入大量精力对氧化石墨烯结构进行工程设计，以增强其类过氧化物酶功能。尽管如此，此类纳米酶的实际应用仍在积极研究中，需要进一步完善。本综述综合了含氮杂原子氧化石墨烯纳米酶及其衍生纳米酶的当前发展情况，强调了最近的突破和生物医学应用。最后探讨了这些材料在生物医学领域的未来发展方向和更广泛的潜力。
