Jamieson T W, De Smet A A, Stechschulte D J
Skeletal Radiol. 1985;14(4):286-90. doi: 10.1007/BF00352621.
Mucin deposition in the skin (scleromyxedema) is a rare disorder with a historically confusing nomenclature. The etiology and pathogenesis of the disease is poorly understood. The precise extent of potential systemic involvement is uncertain but the prevailing hypothesis is that scleromyxedema is a disorder of skin fibroblasts without internal organ involvement. Two patients with scleromyxedema skin lesions are described in whom an erosive arthropathy developed in joints contiguous to clinically involved skin. Because of the absence of other causes of destructive arthritis, it is postulated that the associated skin disease resulted in infiltration of adjacent synovium with subsequent erosions.
皮肤黏蛋白沉积症（硬化性黏液水肿）是一种罕见疾病，其命名在历史上一直较为混乱。该疾病的病因和发病机制尚不清楚。潜在全身受累的确切程度尚不确定，但普遍的假说是硬化性黏液水肿是一种皮肤成纤维细胞疾病，不累及内脏器官。本文描述了两名患有硬化性黏液水肿皮肤病变的患者，他们在临床上受累皮肤相邻的关节发生了侵蚀性关节病。由于不存在其他导致破坏性关节炎的原因，推测相关的皮肤疾病导致相邻滑膜浸润，随后发生侵蚀。
