Inthavong Donekham, Elsayed Hend, Keonakhone Phonesavanh, Seevisay Vilath, Souksanh Somdeth, Suthepmany Sakhone, Chanthavong Misouk, Keodavong Xaysomvang, Kommanivanh Phonesavanh, Siphanthong Phitsada, Sengmany Phengsy, Sisounon Buahome, Sebert Jacques, Yanagawa Manami, Morishita Fukushi, Nishikiori Nobuyuki, Yamanaka Takuya
National Tuberculosis Control Centre, Vientiane 01160, Laos.
Integrated Communicable Disease Control, World Health Organization Regional Office for the Western Pacific, Manila 1000, Philippines.
Trop Med Infect Dis. 2025 Jul 15;10(7):198. doi: 10.3390/tropicalmed10070198.
Tuberculosis (TB) and undernutrition are intricately linked, significantly impacting health outcomes. However, nutritional support for TB patients is not systematically implemented in Lao People's Democratic Republic (Lao PDR). This study evaluated the effects of nutritional counselling and support on nutritional recovery and TB treatment outcomes. A longitudinal study involved 297 individuals with drug-susceptible TB, 39.4% of whom had a body mass index (BMI) below 18.5 kg/m. Participants were divided into an observation group and an intervention group, the latter receiving nutritional support. Nutritional support included ready-to-use therapeutic food and therapeutic milk products, tailored to patients' nutritional status. Data collection was conducted at four intervals during treatment. By the end of treatment, 84.3% of participants improved their nutritional status to a BMI of 18.5 kg/m or higher. The intervention group showed early nutritional recovery, particularly during the intensive phase of TB treatment, although the -value ( = 0.067) should be interpreted with caution. The overall treatment success rate was high at 90.6%, with no significant difference between groups. Factors associated with treatment success included age under 45, HIV-negative status, a BMI of 18.5 kg/m or higher, and clinically diagnosed pulmonary TB. Further assessment is required for the operational feasibility to provide systematic nutritional assessment and counselling for people with TB in Lao PDR.
结核病（TB）与营养不良密切相关，对健康结果有重大影响。然而，在老挝人民民主共和国（老挝），并未系统地为结核病患者提供营养支持。本研究评估了营养咨询与支持对营养恢复及结核病治疗结果的影响。一项纵向研究纳入了297例药物敏感型结核病患者，其中39.4%的人体质量指数（BMI）低于18.5kg/m²。参与者被分为观察组和干预组，干预组接受营养支持。营养支持包括根据患者营养状况定制的即食治疗食品和治疗性奶制品。在治疗期间分四个时间点进行数据收集。到治疗结束时，84.3%的参与者营养状况改善至BMI为18.5kg/m²或更高。干预组显示出早期营养恢复，尤其是在结核病治疗的强化期，不过对P值（P = 0.067）的解读应谨慎。总体治疗成功率较高，为90.6%，两组之间无显著差异。与治疗成功相关的因素包括年龄在45岁以下、HIV阴性状态、BMI为18.5kg/m²或更高以及临床诊断为肺结核。需要进一步评估在老挝为结核病患者提供系统营养评估和咨询的操作可行性。
