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HIV患者的双侧异位妊娠及改良算法

Bilateral ectopic pregnancy in patient with HIV and modified algorithm.

作者信息

Edwards Dominic Joseph Alexander, Smyth Annabel

机构信息

Obstetrics and Gynaecology, Mater Mothers' Hospital, Brisbane, Queensland, Australia

School of Medicine, The University of Queensland, Brisbane, Queensland, Australia.

出版信息

BMJ Case Rep. 2025 Jul 25;18(7):e266357. doi: 10.1136/bcr-2025-266357.

DOI:10.1136/bcr-2025-266357
PMID:40713070
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12305758/
Abstract

This case report describes a rare occurrence of spontaneous bilateral ectopic pregnancy (BEP) in a woman in her 30s, at approximately 7 weeks of gestation in Western Uganda. The patient presented with worsening lower abdominal pain, light vaginal bleeding and vomiting. Initial transvaginal ultrasound suggested a unilateral ectopic pregnancy; however, subsequent imaging and intraoperative findings confirmed bilateral ampullary ectopic pregnancies, one of which had ruptured. This woman had a recent diagnosis of HIV on antiretroviral therapy; she otherwise had no history of assisted reproductive technologies or other risk factors. This case highlights the diagnostic challenges of BEP, emphasising the importance of thorough adnexal evaluation during imaging and intraoperative assessment. The report contributes to existing literature by discussing risk factors and management strategies while advocating for heightened clinical awareness, especially in resource-limited settings. A modified algorithm is attached to guide clinical decision-making regarding suspected BEP. .

摘要

本病例报告描述了乌干达西部一名30多岁女性在妊娠约7周时罕见的自发性双侧异位妊娠(BEP)情况。患者出现下腹部疼痛加剧、少量阴道出血和呕吐症状。最初的经阴道超声检查提示单侧异位妊娠;然而,后续的影像学检查和术中发现证实为双侧壶腹部异位妊娠,其中一侧已破裂。该女性最近被诊断出感染艾滋病毒并正在接受抗逆转录病毒治疗;除此之外,她没有辅助生殖技术史或其他危险因素。本病例突出了BEP的诊断挑战,强调了在影像学检查和术中评估期间对附件进行全面评估的重要性。该报告通过讨论危险因素和管理策略,同时倡导提高临床意识,特别是在资源有限的环境中,为现有文献做出了贡献。附上了一种改良算法,以指导关于疑似BEP的临床决策。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ebc/12305758/2154d79120f3/bcr-18-7-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ebc/12305758/9a5ed22065db/bcr-18-7-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ebc/12305758/9c2c3d3afe23/bcr-18-7-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ebc/12305758/86e56aed4b67/bcr-18-7-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ebc/12305758/2154d79120f3/bcr-18-7-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ebc/12305758/9a5ed22065db/bcr-18-7-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ebc/12305758/9c2c3d3afe23/bcr-18-7-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ebc/12305758/86e56aed4b67/bcr-18-7-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ebc/12305758/2154d79120f3/bcr-18-7-g004.jpg

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本文引用的文献

1
Role of Dolutegravir/Lamivudine in the Management of Pregnant People Living with HIV-1: A Narrative Review.多替拉韦/拉米夫定在HIV-1感染孕妇管理中的作用:一项叙述性综述
Infect Dis Ther. 2025 Jan;14(1):59-80. doi: 10.1007/s40121-024-01085-z. Epub 2024 Dec 9.
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Global burden and trends of ectopic pregnancy: An observational trend study from 1990 to 2019.全球异位妊娠负担和趋势:1990 年至 2019 年的观察性趋势研究。
PLoS One. 2023 Oct 26;18(10):e0291316. doi: 10.1371/journal.pone.0291316. eCollection 2023.
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Abdominal ectopic pregnancy.
腹腔妊娠。
BMJ Case Rep. 2023 Sep 29;16(9):e252960. doi: 10.1136/bcr-2022-252960.
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The association between the prevalence of HIV infection and ectopic pregnancy.HIV 感染的流行与宫外孕之间的关联。
Afr J Reprod Health. 2023 Feb;27(2):87-91. doi: 10.29063/ajrh2023/v27i2.9.
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Spontaneous bilateral tubal ectopic pregnancy preoperatively diagnosed by the ultrasound: a case report.超声术前诊断双侧输卵管自发性宫外孕:病例报告。
BMC Pregnancy Childbirth. 2023 Feb 23;23(1):125. doi: 10.1186/s12884-023-05458-z.
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Simultaneous bilateral fallopian tubal pregnancy of a laparoscopic definite spontaneous unilateral ovulation: a case report.腹腔镜明确自发单侧排卵时双侧输卵管同时妊娠:病例报告。
BMC Pregnancy Childbirth. 2022 Feb 10;22(1):110. doi: 10.1186/s12884-022-04453-0.
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Ectopic pregnancy: a resident's guide to imaging findings and diagnostic pitfalls.宫外孕:影像学表现及诊断陷阱——住院医师指南
Emerg Radiol. 2022 Feb;29(1):161-172. doi: 10.1007/s10140-021-01974-7. Epub 2021 Oct 7.
8
Spontaneous bilateral tubal ectopic pregnancy: a case report.自发性双侧输卵管异位妊娠:病例报告。
Pan Afr Med J. 2021 Apr 23;38:395. doi: 10.11604/pamj.2021.38.395.28771. eCollection 2021.
9
Spontaneous Ruptured Bilateral Tubal Ectopic Pregnancy Following Natural Conception: A Rare Case Report.自然受孕后双侧输卵管妊娠自发性破裂:一例罕见病例报告
J Hum Reprod Sci. 2021 Apr-Jun;14(2):196-199. doi: 10.4103/jhrs.JHRS_87_20. Epub 2021 Jun 28.
10
Tubal ectopic pregnancy occurrence is associated with high expressions of prokineticin receptors and aberrant secretion of inflammatory cytokines.输卵管异位妊娠的发生与促动力蛋白受体的高表达及炎性细胞因子的异常分泌有关。
Am J Transl Res. 2020 Sep 15;12(9):5741-5751. eCollection 2020.