组学数据集可以弥合肿瘤生物学与患者护理之间的差距。
Omics datasets can bridge the gap between tumor biology and patient care.
作者信息
Huang Ji-Ting, Dai Lei-Jie, Ma Ding, Shao Zhi-Ming
机构信息
Department of Breast Surgery, Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center, Shanghai, China.
Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
出版信息
PLoS Biol. 2025 Jul 28;23(7):e3003279. doi: 10.1371/journal.pbio.3003279. eCollection 2025 Jul.
Abstract
Large-scale omics datasets from tumor samples are becoming ever easier to generate and analyze. As technology continues to push forward, how can this data be leveraged to help patients in the clinic?
摘要
来自肿瘤样本的大规模组学数据集正变得越来越容易生成和分析。随着技术不断向前发展，如何利用这些数据来帮助临床中的患者呢？
相似文献
1
Omics datasets can bridge the gap between tumor biology and patient care.组学数据集可以弥合肿瘤生物学与患者护理之间的差距。
PLoS Biol. 2025 Jul 28;23(7):e3003279. doi: 10.1371/journal.pbio.3003279. eCollection 2025 Jul.
2
An Analytical Approach that Combines Knowledge from Germline and Somatic Mutations Enhances Tumor Genomic Reanalyses in Precision Oncology.一种结合种系和体细胞突变知识的分析方法可增强精准肿瘤学中的肿瘤基因组再分析。
J Comput Biol. 2025 Jan;32(1):89-103. doi: 10.1089/cmb.2023.0461. Epub 2024 Dec 11.
3
Characterizing the omics landscape based on 10,000+ datasets.基于一万多个数据集描绘组学全景。
Sci Rep. 2025 Jan 25;15(1):3189. doi: 10.1038/s41598-025-87256-5.
4
Molecular feature-based classification of retroperitoneal liposarcoma: a prospective cohort study.基于分子特征的腹膜后脂肪肉瘤分类：一项前瞻性队列研究。
Elife. 2025 May 23;14:RP100887. doi: 10.7554/eLife.100887.
5
Gene regulatory network integration with multi-omics data enhances survival predictions in cancer.基因调控网络与多组学数据的整合提高了癌症生存预测能力。
Brief Bioinform. 2025 Jul 2;26(4). doi: 10.1093/bib/bbaf315.
6
Deep Genomics: Deep Learning-Based Analysis of Genome-Sequenced Data for Identification of Gene Alterations.深度基因组学：基于深度学习的基因组测序数据分析以识别基因改变
Methods Mol Biol. 2025;2952:335-367. doi: 10.1007/978-1-0716-4690-8_20.
7
CrossAttOmics: multiomics data integration with cross-attention.交叉注意力组学：基于交叉注意力的多组学数据整合
Bioinformatics. 2025 Jun 2;41(6). doi: 10.1093/bioinformatics/btaf302.
8
Integrative AI-Based Approaches to Connect the Multiome to Use Microbiome-Metabolome Interactive Outcome as Precision Medicine.基于整合人工智能的方法将多组学联系起来，以微生物组-代谢组相互作用结果作为精准医学的依据。
Methods Mol Biol. 2025;2952:15-37. doi: 10.1007/978-1-0716-4690-8_2.
9
Examining How Technology Supports Shared Decision-Making in Oncology Consultations: Qualitative Thematic Analysis.审视技术如何支持肿瘤学会诊中的共同决策：定性主题分析
JMIR Cancer. 2025 Jun 11;11:e70827. doi: 10.2196/70827.
10
Can a Liquid Biopsy Detect Circulating Tumor DNA With Low-passage Whole-genome Sequencing in Patients With a Sarcoma? A Pilot Evaluation.液体活检能否通过低深度全基因组测序检测肉瘤患者的循环肿瘤DNA？一项初步评估。
Clin Orthop Relat Res. 2025 Jan 1;483(1):39-48. doi: 10.1097/CORR.0000000000003161. Epub 2024 Jun 21.
引用本文的文献
1
Unveiling cancer crosstalk: Mapping complexity across time and space.揭示癌症间的相互作用：描绘时空复杂性。
PLoS Biol. 2025 Jul 29;23(7):e3003326. doi: 10.1371/journal.pbio.3003326. eCollection 2025 Jul.
本文引用的文献
1
Neuronal FAM171A2 mediates α-synuclein fibril uptake and drives Parkinson's disease.神经元FAM171A2介导α-突触核蛋白原纤维摄取并引发帕金森病。
Science. 2025 Feb 21;387(6736):892-900. doi: 10.1126/science.adp3645. Epub 2025 Feb 20.
2
Optimising first-line subtyping-based therapy in triple-negative breast cancer (FUTURE-SUPER): a multi-cohort, randomised, phase 2 trial.优化三阴性乳腺癌（FUTURE-SUPER）一线基于亚型的治疗：多队列、随机、2 期试验。
Lancet Oncol. 2024 Feb;25(2):184-197. doi: 10.1016/S1470-2045(23)00579-X. Epub 2024 Jan 8.
3
Molecular classification of hormone receptor-positive HER2-negative breast cancer.激素受体阳性 HER2 阴性乳腺癌的分子分类。
Nat Genet. 2023 Oct;55(10):1696-1708. doi: 10.1038/s41588-023-01507-7. Epub 2023 Sep 28.
4
Zolbetuximab plus CAPOX in CLDN18.2-positive gastric or gastroesophageal junction adenocarcinoma: the randomized, phase 3 GLOW trial.Zolbetuximab 联合 CAPOX 方案治疗 Claudin18.2 阳性胃或胃食管结合部腺癌：一项随机、III 期 GLOW 试验
Nat Med. 2023 Aug;29(8):2133-2141. doi: 10.1038/s41591-023-02465-7. Epub 2023 Jul 31.
5
Olaparib plus bevacizumab first-line maintenance in ovarian cancer: final overall survival results from the PAOLA-1/ENGOT-ov25 trial.奥拉帕利联合贝伐珠单抗一线维持治疗卵巢癌：PAOLA-1/ENGOT-ov25 试验的最终总生存结果。
Ann Oncol. 2023 Aug;34(8):681-692. doi: 10.1016/j.annonc.2023.05.005. Epub 2023 May 19.
6
Subtyping-based platform guides precision medicine for heavily pretreated metastatic triple-negative breast cancer: The FUTURE phase II umbrella clinical trial.基于亚型的平台指导了对经大量预处理的转移性三阴性乳腺癌的精准医学治疗：FUTURE 二期伞式临床试验。
Cell Res. 2023 May;33(5):389-402. doi: 10.1038/s41422-023-00795-2. Epub 2023 Mar 27.
7
Genomic and Transcriptomic Landscape of Triple-Negative Breast Cancers: Subtypes and Treatment Strategies.三阴性乳腺癌的基因组和转录组全景：亚型和治疗策略。
Cancer Cell. 2019 Mar 18;35(3):428-440.e5. doi: 10.1016/j.ccell.2019.02.001. Epub 2019 Mar 7.
8
Homologous Recombination Deficiency (HRD) Score Predicts Response to Platinum-Containing Neoadjuvant Chemotherapy in Patients with Triple-Negative Breast Cancer.同源重组缺陷（HRD）评分可预测三阴性乳腺癌患者对含铂新辅助化疗的反应。
Clin Cancer Res. 2016 Aug 1;22(15):3764-73. doi: 10.1158/1078-0432.CCR-15-2477. Epub 2016 Mar 8.
9
Supervised risk predictor of breast cancer based on intrinsic subtypes.基于内在亚型的乳腺癌监督风险预测器
J Clin Oncol. 2009 Mar 10;27(8):1160-7. doi: 10.1200/JCO.2008.18.1370. Epub 2009 Feb 9.
10
Claudin-18 splice variant 2 is a pan-cancer target suitable for therapeutic antibody development.Claudin-18剪接变体2是一种适用于治疗性抗体开发的泛癌靶点。
Clin Cancer Res. 2008 Dec 1;14(23):7624-34. doi: 10.1158/1078-0432.CCR-08-1547.
Zotero 插件