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本文引用的文献

1
Omics datasets can bridge the gap between tumor biology and patient care.组学数据集可以弥合肿瘤生物学与患者护理之间的差距。
PLoS Biol. 2025 Jul 28;23(7):e3003279. doi: 10.1371/journal.pbio.3003279. eCollection 2025 Jul.
2
TiME for a change: The tumor microenvironment as the missing piece in cancer therapeutics.是时候做出改变了：肿瘤微环境是癌症治疗中缺失的一环。
PLoS Biol. 2025 Jul 24;23(7):e3003276. doi: 10.1371/journal.pbio.3003276. eCollection 2025 Jul.
3
Challenges and opportunities for the next generation of computational tumor models.下一代计算肿瘤模型面临的挑战与机遇。
PLoS Biol. 2025 Jul 23;23(7):e3003269. doi: 10.1371/journal.pbio.3003269. eCollection 2025 Jul.
4
Can the tumor neural niche be targeted to re-program cancer?肿瘤神经微环境能否成为重新编程癌症的靶点？
PLoS Biol. 2025 Jul 21;23(7):e3003266. doi: 10.1371/journal.pbio.3003266. eCollection 2025 Jul.
5
Applying multilevel selection to understand cancer evolution and progression.应用多层次选择来理解癌症的演变和进展。
PLoS Biol. 2025 Jul 18;23(7):e3003290. doi: 10.1371/journal.pbio.3003290. eCollection 2025 Jul.
6
Masters of adaptation: How cancer and immune cell plasticity mediates tumor progression.适应大师：癌症与免疫细胞可塑性如何介导肿瘤进展
PLoS Biol. 2025 Jul 15;23(7):e3003301. doi: 10.1371/journal.pbio.3003301. eCollection 2025 Jul.
7
Decoding metastatic microenvironments through single-cell omics reveals new insights into niche dynamics and tumor evolution.通过单细胞组学解码转移性微环境揭示了生态位动态和肿瘤进化的新见解。
PLoS Biol. 2025 Jul 14;23(7):e3003299. doi: 10.1371/journal.pbio.3003299. eCollection 2025 Jul.
8
Bi-directional metabolic reprogramming between cancer cells and T cells reshapes the anti-tumor immune response.癌细胞与T细胞之间的双向代谢重编程重塑了抗肿瘤免疫反应。
PLoS Biol. 2025 Jul 14;23(7):e3003284. doi: 10.1371/journal.pbio.3003284. eCollection 2025 Jul.
9
Embracing cancer complexity: Hallmarks of systemic disease.拥抱癌症的复杂性：全身性疾病的特征。
Cell. 2024 Mar 28;187(7):1589-1616. doi: 10.1016/j.cell.2024.02.009.
10
The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth.不断演变的肿瘤微环境：从癌症起始到转移灶生长
Cancer Cell. 2023 Mar 13;41(3):374-403. doi: 10.1016/j.ccell.2023.02.016.

揭示癌症间的相互作用：描绘时空复杂性。

Unveiling cancer crosstalk: Mapping complexity across time and space.

作者信息

Kang Yibin

机构信息

Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America.

Ludwig Institute for Cancer Research Princeton Branch, Princeton, New Jersey, United States of America.

出版信息

PLoS Biol. 2025 Jul 29;23(7):e3003326. doi: 10.1371/journal.pbio.3003326. eCollection 2025 Jul.

DOI:10.1371/journal.pbio.3003326
PMID:40729309
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12306726/
Abstract

Cancer evolves through dynamic exchanges with its environment, harnessing these interactions to grow, adapt, and transcend the constraints that would otherwise limit its progress. A new collection of articles explores this tumor-environment crosstalk across temporal and spatial scales.

摘要

癌症通过与周围环境的动态交互而演变，利用这些相互作用来生长、适应并突破那些原本会限制其发展的约束条件。一组新的文章探讨了这种肿瘤与环境在时间和空间尺度上的相互作用。