Salima Siti, Sampeliling Dave Grant, Permadi Wiryawan, Sasotya R M Sonny, Aziz M Alamsyah, Kurniadi Andi, Nisa Aisyah Shofiatun
Department of Obstetric and Gynecology, Faculty of Medicine, Padjajaran University Dr. Hasan Sadikin General Hospital, Pasteur No. 38, Bandung, 40161, West Java, Indonesia.
BMC Res Notes. 2025 Jul 28;18(1):328. doi: 10.1186/s13104-025-07330-z.
Ovarian cancer is the leading cause of death from gynecological cancers. In the early stages, it is generally asymptomatic, leading to delays in the early diagnosis of ovarian cancer. Inflammation, which is the body's response to tissue damage, plays a crucial role in the pathogenesis of cancer. Inflammatory responses result in cellular changes, damaged tissue repair, and affected area proliferation. This research aims to determine the differences in LMR (Lymphocyte-to-Monocyte Ratio), PLR (Platelet-to-Lymphocyte Ratio), and SIRI (Systemic Immune-Inflammation Index), which were the parameters of inflammation between ovarian malignant tumors and benign ovarian tumors.
This retrospective cohort study analyzed medical records of 327 patients treated at Dr. Hasan Sadikin General Hospital, Bandung, between 2020 and 2022, including 166 cases of malignant ovarian tumors and 161 benign ovarian tumors. Inflammatory markers were calculated from routine blood counts. The mean LMR was significantly lower in the malignant group than the benign group (3.32 vs. 3.83, P = 0.004). Conversely, PLR and SIRI values were significantly higher in malignant tumors (PLR: 355 vs. 213, P = 0.001; SIRI: 3.50 vs. 2.97, P = 0.042). These findings suggest that LMR, PLR, and SIRI may serve as supportive inflammatory biomarkers in distinguishing malignant from benign ovarian tumors.
卵巢癌是妇科癌症致死的主要原因。在早期阶段，它通常没有症状，导致卵巢癌早期诊断延迟。炎症是身体对组织损伤的反应，在癌症发病机制中起关键作用。炎症反应导致细胞变化、受损组织修复和受影响区域增殖。本研究旨在确定淋巴细胞与单核细胞比值（LMR）、血小板与淋巴细胞比值（PLR）和全身免疫炎症指数（SIRI）在卵巢恶性肿瘤和卵巢良性肿瘤之间作为炎症参数的差异。
这项回顾性队列研究分析了2020年至2022年期间在万隆哈桑·萨迪金综合医院接受治疗的327例患者的病历，其中包括166例恶性卵巢肿瘤和161例良性卵巢肿瘤。炎症标志物通过血常规计算得出。恶性组的平均LMR显著低于良性组（3.32对3.83，P = 0.004）。相反，恶性肿瘤中的PLR和SIRI值显著更高（PLR：355对213，P = 0.001；SIRI：3.50对2.97，P = 0.042）。这些发现表明，LMR、PLR和SIRI可能作为支持性炎症生物标志物，用于区分恶性和良性卵巢肿瘤。
